Randomized study of clinical effect of enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer
Clinical Nutrition,  Clinical Article

Miyata H et al. – Compared with PN support, Enteral nutrition (EN) support during neoadjuvant chemotherapy reduced the incidence of chemotherapy–related hematological toxicities in patients with esophageal cancers.

Methods
  • Ninety-one patients who received neoadjuvant chemotherapy (5-fluorouracil, cisplatin and adriamycin) for esophageal cancer were enrolled to receive either EN (n=47) or PN (n=44) at random.
  • The primary endpoint was the incidence of chemotherapy-related toxicities during chemotherapy.

Results
  • Total and dietary intake calories during chemotherapy were equal in the two groups.
  • There were no significant differences in serum albumin level and body weight change after chemotherapy between the two groups.
  • There was no significant difference in tumor response to chemotherapy between the two groups (EN: 51%, PN: 55%, p = 0.886).
  • Leukopenia and neutropenia of grade 3 or 4, defined according to the Common Toxicities Criteria of the National Cancer Institute, were significantly less frequent in the EN group than PN group (leukopenia: 17% vs 41%, p = 0.011, neutropenia: 36% vs 66%, p = 0.005).
  • Lymphopenia and thrombocytopenia tended to be less frequent in the EN group, albeit insignificantly.

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