Body mass index and lung cancer risk: results from the ICARE study, a large, population-based case-control study
Cancer Causes and Control, 05/25/2012
Tarnaud C et al. – We found an inverse dose-dependent association between lung cancer risk and BMI 2 years prior to interview in current smokers.Methods
- A total of 2,625 incident lung cancer cases and 3,381 controls were included.
- Weight was collected at interview, 2 years before the interview, and at age 30.
- Lifetime smoking exposure was calculated using the comprehensive smoking index (CSI).
- Adjusted odds ratios (aORs) and 95 % confidence intervals were estimated by unconditional logistic regression and controlled for age, area, education, CSI, occupational exposure, previous chronic bronchitis, and parental history of lung cancer.
- We also examined the role of weight change.
- Analyses were stratified by smoking status and sex.
- When compared with that of men with normal BMI 2 years before the interview, lung cancer aORs (95 % CI) among men with BMIs of <18.5, 25–29.9, 30–32.4, and ?32.5 kg/m² were 2.7 (95 % CI 1.2–6.2), 0.9 (95 % CI 0.7–1.1), 0.8 (95 % CI 0.6–1.1), and 0.8 (95 % CI 0.6–1.0), respectively (p trend = 0.02).
- Results were more pronounced among current smokers and were similar in men and women.
- Weight gain over time was associated with a significant decreased risk of lung cancer.