Phase II and gene expression analysis trial of neoadjuvant capecitabine plus irinotecan followed by capecitabine-based chemoradiotherapy for locally advanced rectal cancer
Cancer Chemotherapy and Pharmacology, 05/25/2012
Chiorean EG et al. – This neoadjuvant regimen was safe and demonstrated significant antitumor activity. High thymidine phosphorylase (TP) tumor gene expression was associated with obtaining pathological complete response (pCR).