Evidence for BCR-ABL-dependent dysfunctions of iNKT cells from chronic myeloid leukemia patients
European Journal of Immunology, 05/15/2012
Rossignol A et al. – The data demonstrate that chronic phase chronic myeloid leukemia (CML) is associated with functional deficiencies of invariant NKT (iNKT) cells, that are restored upon remission. These results suggest a possible contribution to disease control by tyrosine–kinase (TK) inhibitor therapies.