Relative imbalances in the expression of catechol-O-methyltransferase and cytochrome P450 in breast cancer tissue and their association with breast carcinoma
Maturitas,

Zhao YN et al. – Significantly deceased expression of estradiol–metabolizing enzymes might result in the excess exposure of intratumoural E2, which could be one of the important risk factors for breast cancer. Significantly elevated COMT expression suggested that COMT could play a key role in breast tumor formation.

Methods
  • The mRNA expression levels of cytochrome P450 (CYP) 1A1, 1B1 and 3A4 and catechol–O–methyltransferase (COMT) were examined in the breast tumor tissues, matched adjacent non–tumor tissues and the tissues with benign breast disease (BBD) by fluorescent quantitative real–time PCR.

Results
  • Compared to BBD tissue, the mRNA expression of CYP1A1, CYP1B1 and CYP3A4 significantly reduced by 81.8%, 77.5%, and 85.6%, respectively, in the breast tumor tissue and by 27.2%, 38.8%, and 51.3%, respectively, in the adjacent non–tumor tissue in average (p<0.0001).
  • COMT mRNA was 6.9 and 6.4 fold higher in the breast tumor and match non–tumor tissue (p<0.0001) than in the BBD, respectively.
  • The level of COMT detected in pre–menopausal group and lymph nodal stage N1–N2 group was lower than that in post–menopausal group (p=0.0292) and N0 group (p=0.0389), respectively.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Oncology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Oncology Articles

1 Vasectomy and risk of aggressive prostate cancer: a 24-year follow-up study Journal of Clinical Oncology, July 17, 2014

2 Calcium, vitamin D, dairy products, and mortality among colorectal cancer survivors: The Cancer Prevention Study-II Nutrition Cohort Journal of Clinical Oncology, July 9, 2014    Clinical Article

3 Rituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial The Lancet Oncology, March 7, 2014    Clinical Article

4 Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: The EVOLVE-1 randomized clinical trial JAMA, July 7, 2014    Evidence Based Medicine    Clinical Article

5 Coffee intake and gastric cancer risk Cancer Epidemiology, Biomarkers & Prevention, March 20, 2014    Clinical Article

6 Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia New England Journal of Medicine, June 4, 2014    Evidence Based Medicine    Clinical Article

7 Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

8 Randomized phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA) Journal of Clinical Oncology, May 29, 2014    Clinical Article

9 Efficacy and safety of maintenance pemetrexed in patients with advanced nonsquamous non-small cell lung cancer following pemetrexed plus cisplatin induction treatment: a cross-trial comparison of two phase III trials Lung Cancer, July 22, 2014    Clinical Article

10 A randomised phase II study of pemetrexed versus pemetrexed+erlotinib as second-line treatment for locally advanced or metastatic non-squamous non-small cell lung cancer European Journal of Cancer, May 23, 2014    Clinical Article

11 Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: The FACS randomized clinical trial Full Text JAMA, January 16, 2014    Free full text    Evidence Based Medicine    Clinical Article

12 Risks of endometrial cancer associated with different hormone replacement therapies in the E3N cohort, 1992–2008 American Journal of Epidemiology, July 18, 2014    Clinical Article

13 The association of vitamin D supplementation with the risk of cancer in postmenopausal women Cancer Causes and Control, December 18, 2013    Clinical Article

14 Dietary one-carbon nutrient intake and risk of lymphoid and myeloid neoplasms: Results of the Netherlands Cohort Study Cancer Epidemiology, Biomarkers & Prevention, July 29, 2014    Clinical Article

15 Body mass index, diabetes, and triple-negative breast cancer prognosis Breast Cancer Research and Treatment, July 8, 2014

16 Diagnosis and treatment of disseminated intravascular coagulation International Journal of Laboratory Hematology, May 5, 2014    Review Article

17 Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials The Lancet, March 25, 2014    Evidence Based Medicine    Clinical Article

18 Regular aspirin use and risk of multiple myeloma: A prospective analysis in the Health Professionals Follow-up Study and Nurses' Health Study Cancer Prevention Research, December 26, 2013    Clinical Article

19 Impact of trastuzumab treatment beyond disease progression for advanced/metastatic breast cancer on survival – Results from a prospective, observational study in Germany The Breast, July 24, 2014

20 Association between melanocytic nevi and risk of breast diseases: The French E3N Prospective Cohort Full Text PLoS Medicine, July 2, 2014    Free full text    Evidence Based Medicine    Clinical Article

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close