Increased prevalence of vitamin D insufficiency in patients with breast cancer after neoadjuvant chemotherapy
Breast Cancer Research and Treatment, 05/11/2012
Jacot W et al. – Calcium and RANKL serum concentrations were also significantly decreased, while OPG was significantly increased, resulting in lower RANKL/OPG ratio. Calcium and vitamin D, RANKL and vitamin D and RANKL and OPG levels were significantly correlated. Nearly all included patients suffered from vitamin D insufficiency by the end of the neoadjuvant chemotherapy with changes in the calcium/RANKL/OPG axis that are evocative of deregulation of a functional regulatory mechanism
