Pathological complete response in younger and older breast cancer patients
Archives of Medical Science, 05/18/2012
Kolacinska A et al. – Pathologic complete response was significantly associated with receptor– based subtypes in both young and old women.Methods
- One hundred thirty–eight consecutive patients aged between 30 and 78 years with locally advanced breast cancer, operated on after neoadjuvant systemic treatment between November 2007 and June 2010, were analyzed.
- In this group 9 women (6.5%) were 40 years of age or younger, and 12 patients (8.7%) were 70 years of age or older.
- In the younger group, pCR was achieved in 1 patient with triple negative, invasive ductal breast cancer, G3, BRCA 1 mutation, treated with cisplatin.
- A near pCR was achieved in 2 other patients, with triple negative, invasive ductal breast cancer, G3, treated with AT.
- The pCR in the breast was found in a HER2 positive patient.
- In older patients, pCR was achieved in 2 patients with triple negative, invasive ductal breast cancer, G3, treated with AT or FEC.
- Pathologic complete response in the axilla was achieved in 1 patient with triple negative, ductal carcinoma.
- The pCR rates were significantly higher in triple negative breast cancer in both groups (p = 0.047 and p = 0.018, respectively).