mdlinx mdlinx
Latest (9) Full Text Articles (1364) Focus on Urology Article Summary

Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption and breast cancer
Cancer Epidemiology, Biomarkers & Prevention,

Hvidtfeldt UA et al. – The relation of BMI with breast cancer was partly mediated through estradiol and, to a greater extent, through insulin. The findings provide support for evaluation of interventions to lower insulin and estrogen levels in overweight and obese postmenopausal women to reduce breast cancer risk

Methods

  • We combined data from two case-cohort studies based in the Women's Health Initiative Observational Study with serum estradiol levels, one of which also had insulin levels.
  • A total of 1601 women (601 cases) aged 50-79 years who were not using hormone therapy at enrollment were included.
  • Mediating effects were estimated by applying a new method based on the additive hazard model.

Results
  • A 5-unit increase in BMI was associated with 50.0 (95% CI, 23.2; 76.6) extra cases per 100,000 women at risk per year.
  • Of these, 23.8% (95% CI, 2.9; 68.4) could be attributed to estradiol and 65.8% (95% CI, 13.6; 273.3) through insulin pathways.
  • The mediating effect of estradiol was greater (48.8%; 95% CI, 18.8; 161.1) for BMI when restricted to ER+ cases.
  • Consuming 7+ drinks/week compared to abstinence was associated with 164.9 (95% CI, 45.8; 284.9) breast cancer cases per 100,000, but no significant contribution from estradiol was found.
  • The effect of alcohol on breast cancer was restricted to ER+ breast cancers.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Oncology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Oncology Articles

Last month's top read Top Articles of 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

Other Topics in Oncology

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close