hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases
Clinical and Experimental Metastasis, 05/08/2012
Bischoff J et al. – The data showed that hMLH1 methylation with a consequent protein decrease occurred early during EC tumorigenesis and may cause a MSI phenotype, which occurs relatively late. MSI may be an important mechanism supporting further the tumor progression. These findings may have importance for the specific chemosensitization of the primary tumors/metastases and can improve the understanding of endometrial carcinogenesis in humans.