Evaluation of prevalent and incident ovarian cancer co-morbidity
British Journal of Cancer, 05/07/2012
Stalberg K et al. – Women developing ovarian cancer do not have higher overall morbidity the years preceding cancer diagnosis. The incidence of many common diagnoses was increased several years following the ovarian cancer. It is crucial to consider time between co-morbidity and cancer diagnosis to understand and interpret associations.Methods
- The study population was patients with ovarian cancer in Sweden 1993–2006 (n=11?139) and five controls per case (n=55?687).
- Co-morbidity from 1987 to 2006 was obtained from the Swedish Patient Register.
- Prevalent data were analysed with logistic regression and incident data with Cox proportional hazards models.
- Women developing ovarian cancer did not have higher overall morbidity than other women earlier than 3 months preceding cancer diagnosis.
- However, at time of diagnosis 11 of 13 prevalent diagnosis groups were more common among ovarian cancer patients compared with controls.
- The incidence of many common diagnoses was increased several years following the ovarian cancer and the most common diagnoses during the follow-up period were thromboembolism, haematologic and gastrointestinal complications.