FK506 inhibits the enhancing effects of transforming growth factor-β1 on collagen expression and TGF-β/Smad signaling in keloid fibroblasts: Implication for new therapeutic approach
British Journal of Dermatology, 05/21/2012
Wu CS et al. – The results demonstrated that tacrolimus (FK506) effectively blocked the Transforming growth factor–β1 (TGF–β1)–β/Smad signaling pathway in KFs by downregulation of TGF–β receptors and suggested that FK506 may be included in the armamentarium for treating keloids.



