Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case-control study

BMC Gastroenterology, 05/03/2012

Statins use was associated with a protective effect against the development of CRC. This effect is associated with a significant dose and duration response. These findings need to be repeated in other observational studies before an interventional study can be considered.

Methods

  • This was a case-control study examining statin use in symptomatic patients attending for diagnostic colonoscopy.
  • Statin use was compared between patients with CRC and a control group, who had all had normal colonoscopy.
  • Structured interviews and clinical records notes were used to determine drug exposure.
  • Logistic regression was used to compare statin exposure and correct for confounding factors.

Results

  • There was a significant inverse association between previous statin use and a diagnosis of CRC (OR=0.43 (95% confidence interval 0.25-0.80), p<0.01).
  • This inverse association was stronger with higher statin doses (OR = 0.19 (0.07-0.47), p<0.01) and greater duration of statin use (statin use >5 years: OR = 0.18 (0.06-0.55), p<0.01).

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