Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma
Head & Neck, 05/10/2012
Van der Vorst S et al. – Functional analysis of separated alleles in yeast (FASAY) positivity indicates field cancerization in a subgroup of patients with HNSCC, in which nonfunctional p53 was significantly associated with locoregional recurrence. This prompted us to pursue the study on the p53 functional status of normal mucosa in patients with head and neck squamous cell carcinoma (HNSCC).