Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy
British Journal of Dermatology, 04/18/2012Szeimies RM et al.
Clinical and histological improvement in field cancerization after multiple sessions of methylaminolevulinate (MAL)–photodynamic therapy (PDT) is proven. The decrease in severity and extent of keratinocyte atypia associated with a decreased expression of TP–53 suggest a reduced carcinogenic potential of the sun damaged area. The significant increase of new collagen deposition and the reduction of solar elastosis explain the clinical improvement of photodamaged skin.
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