Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy

British Journal of Dermatology, 04/18/2012

Clinical and histological improvement in field cancerization after multiple sessions of methylaminolevulinate (MAL)–photodynamic therapy (PDT) is proven. The decrease in severity and extent of keratinocyte atypia associated with a decreased expression of TP–53 suggest a reduced carcinogenic potential of the sun damaged area. The significant increase of new collagen deposition and the reduction of solar elastosis explain the clinical improvement of photodamaged skin.

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