Comparison of circumferential resection margin clearance criteria with survival after surgery for cancer of esophagus
Journal of Surgical Oncology, 05/03/2012
Rao VSR et al. – This study appears to lend credence to the RCP criteria for definition of circumferential resection margin (CRM) over the college of American Pathologists (CAP) criteria.Methods
- Patients (115) who underwent esophagectomy between 2000 and 2006 were included in this retrospective study.
- Factors such as neo–adjuvant therapy, site, histological type, size, and lymph node involvement were tested to determine predictability of CRM involvement.
- Along with these, age, sex, CRM, and adjuvant therapy were analyzed to determine influence on survival.
- On the basis of CRM, patients were divided into three groups (involved, 0.1–1 mm and >1mm).
- Size (T) was the only factor strongly predictive of CRM involvement (P<0.001).
- Size (T; P=0.04) and lymph node involvement (N; P=0.0003) were found to significantly influence overall survival (OS).
- When patients with CRM (involved and 0.1–1mm) were compared with those with CRM>1 mm, OS was significantly prolonged in the latter (P=0.02).