Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B
International Journal of Cancer, 04/25/2012
Beckham TH et al. – The results demonstrate a novel pathway by which acid ceramidase (AC), through sphingosine–1–phosphate (S1P), promotes an invasive phenotype in prostate cancer by causing overexpression and secretion of cathepsin B through activation and nuclear expression of Ets1. As prostate cancer prognosis is dramatically worse when invasion has occurred, this study provides critical insight into the progression toward lethal prostate cancer.