Molecular Characterization of Human Cutaneous Melanoma-derived Cell Lines
Anticancer Research, 06/12/2012
Ogbah Z et al. – The data suggest the existence of a specific pattern of somatic alterations in genes that are involved in DNA repair (MUTYH) and in cell cycle regulation (c–MYC, CDK6, CDKN2A and CDKN2B). Interestingly, all MC1R variants were associated with BRAFV600E and all cell lines from visceral metastases harboured BRAFV600E.