Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma
Leukemia Research, 03/29/2012
Martino A et al. – Despite the overall negative findings, the authors found a significant age–modified effect of IL6 and TNF–α SNPs, on multiple myeloma (MM) risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation–related genes could be an important mediator of the complex interplay between ageing and cancer.