A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy Full Text
BMC Cancer,  Clinical Article

Lee CE et al. – Musculoskeletal health management remains a challenge in men with prostate cancer receiving androgen deprivation therapy (ADT). This study addresses this issue by designing a simple and accessible home–based walking exercise program that will potentially have significant impact on reducing the risk of fracture, promoting physical function, and ultimately improving the health–related quality of life in men with prostate cancer receiving ADT.

Methods
  • A 12-month prospective, single-blinded, randomized controlled trial will be conducted to compare the Exercise Group with the Control Group.
  • Sixty men with prostate cancer who will be starting ADT will be recruited and randomly assigned to one of the two groups: the Exercise Group will receive instructions in setting up an individualized 12-month home-based walking exercise program, while the Control Group will receive standard medical advice from the attending physician.

Results
  • A number of outcome measures will be used to assess bone health, physical function, and health-related quality of life.
  • At baseline and 12 months, bone health will be assessed using dual-energy X-ray absorptiometry.
  • At baseline and every 3 months up to 12 months, physical function will be evaluated using the Functional Assessment of Chronic Illness Therapy - Fatigue Scale, Activities-specific Balance Confidence Scale, Short Physical Performance Battery, and Six-Minute Walk Test; and health-related quality of life will be assessed using the Functional Assessment of Cancer Therapy Prostate Module and the Medical Outcomes Study 12-item Short Form Health Survey Version 2.
  • A mixed multiple analysis of variance will be used to analyze the data.

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