Protein Z/protein Z-dependent protease inhibitor system in human non-small-cell lung cancer tissue

Thrombosis Research, 04/04/2012

Protein Z–dependent protease inhibitor and PZ expression in non–small–cell lung cancer (NSCLC) cells, Endothelial cells (ECs) and tumor infiltrating macrophages may suggest a role for PZ/ZPI in the anticoagulant mechanisms at the tumor site. The presence of F1+2 and fibrin, along with a disproportional expression of ZPI and PZ, might point to impaired function of the coagulation inhibitory system in NSCLC tissue.

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