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A risk-adapted strategy of adjuvant paclitaxel/carboplatin in early-stage ovarian cancer: Time-dependent effect of 4 versus 6 cycles on outcome
Oncology (Karger), 01/13/2012
Clinical Article
Bamiasa A et al. – Six cycles of chemotherapy reduced the risk of relapse within 2 years, but the benefit from two additional cycles beyond this time is questionable.
Methods- 53 patients were treated according to risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; patients with IC/IIA and grade 2 or 3 (high risk) received 6 cycles of chemotherapy
- Outcome was compared with that of 95 patients who were all treated with 4 cycles
- Median follow-up was 88, 113 and 42 months for the whole cohort, non-risk-adapted and risk-adapted treatment
- 5-year relapse-free and disease-specific survival was 86 and 93% for the whole population, 96 and 97% for low-risk and 81 and 91% for high-risk patients
- Risk classification was only significant prognostic factor for relapse-free (p = 0.011) and disease-specific survival (p = 0.039)
- Among high-risk patients, administration of 6 cycles was associated with significantly lower relapse rate after censoring events, which occurred beyond 2 years (3 vs. 18%; p = 0.013), but this difference was diminished at 5 years (23 vs. 25%; p = 0.797)