Racial disparities in Hodgkin's lymphoma: A comprehensive population-based analysis
Annals of Oncology, 01/13/2012
Evens AM et al –The authors identified multiple racial disparities, including survival, in adolescent/adult HL.
Methods- Examined time-, age-, and gender-specific incidence, disease characteristics, and survival across and within races for adolescent/adult HL (age 10–79 years) diagnosed during 1992–2007 in the SEER 13 registries
- 15,662 HL cases were identified [11,211 non-Hispanic whites, 2067 Hispanics, 1662 blacks, and 722 Asian/Pacific Islanders (A/PI)]. Similar to whites, A/PIs had bimodal age-specific incidence, while blacks and Hispanics did not
- Further, HL was significantly more common in Hispanics versus whites age >65 years (7.0/1 × 106 versus 4.5/1 × 106, respectively, P < 0.01)
- By place of birth, US-born Hispanics and A/PIs age 20–39 years had higher incidence of HL versus their foreign-born counterparts (P < 0.05), however, rates converged age >40 years Interestingly, from 1992–1997 to 2003–2007, A/PI incidence rates increased >50% (P < 0.001)
- Moreover, this increase was restricted to US-born A/PI
- Identified a number of disease-related differences based on race
- Finally, 5-, 10-, and 15-year OS rates were inferior for blacks and Hispanics compared with whites (P < 0.005 and P < 0.001, respectively) and A/PI (P < 0.018 and P < 0.001, respectively)
- These differences persisted on multivariate analysis
