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Local breast cancer recurrence after mastectomy and immediate breast reconstruction for invasive cancer: A meta-analysis
The Breast, 01/10/2012
Clinical Article
Gieni M et al. – This meta–analysis demonstrated no evidence for increased frequency of local breast cancer recurrence with IBR compared with mastectomy alone.
Methods- 2 independent investigators searched PubMed, Embase, and the Cochrane database using predefined search terms
- After application of inclusion and exclusion criteria, 10 articles remained
- Each article was assessed for quality
- Relevant data was collected including recurrence rates, cancer stage, type of mastectomy and reconstruction, adjuvant treatments, and duration of follow–up
- Inter–rater reliability was good at 74% (95% CI: 0, 93%)
- No evidence of study heterogeneity (p for Q–statistic=0.34 and I2=12%)
- OR ratio for recurrence of breast cancer for mastectomy with IBR as compared to mastectomy alone was 0.98 (95% CI: 0.62, 1.54)