Increasing incidence in liver cancer in Canada, 1972-2006: Age-period-cohort analysis Full Text
Journal of Gastrointestinal Oncology, 10/03/2011
Jiang XH et al. – The age-period-cohort analysis suggests that birth-cohort effect is underlying the increase in incidence. While the exact reason for the increased incidence of liver cancer remains unknown, reported increase in HBV and HCV infections, and immigration from high-risk regions of the world may be important factors.
Methods- Analyzed data obtained from Canadian Cancer Registry Database and Canadian Vital Statistics Death Database
- Examined temporal trends by sex, age group, and birth cohort between 1972 and 2006
- 3–year period rates and annual percentage change (APC) were calculated to compare changes over study period
- Used age-period-cohort modelling to estimate underlying effects on observed trends in incidence
- Overall age-adjusted incidence rates increased from 2.6 and 1.5 per 100 000 in 1972–74 to 6.5 (APC: 2.9) and 2.2 (APC: 1.2) per 100 000 in 2004–06 among males and females
- Age-adjusted mortality rates increased from 3.3 and 2.0 per 100 000 in 1972–74 to 6.0 (APC: 2.3) and 2.6 (APC: 1.2) per 100 000 in 2004–06 among males and females, respectively
- Incidence increased most rapidly in men aged 45–54 years (APC: 4.1) and women aged 65–74 years (APC: 1.7) over period of study
