The company malaria keeps: how co-infection with Epstein–Barr virus leads to endemic Burkitt lymphoma
Current Opinion in Infectious Diseases, 09/02/2011
Moormann A et al. – Epstein–Barr virus (EBV) is necessary but not sufficient to cause endemic Burkitt lymphoma (eBL). A more dynamic model encompasses incremental contributions from both chronic and acute Plasmodium falciparum malaria leading to alterations in EBV persistence and EBV–specific immunity that culminate in eBL. A better understanding of how P. falciparum malaria modifies EBV infections in children may allow us to anticipate reductions in eBL incidence coinciding with malaria control programs.
