Effect of intersubject variability of extrathoracic morphometry, lung airways dimensions and respiratory parameters on particle deposition Full Text
Journal of Thoracic Disease,
Hussain M et al. – The variability of deposition fractions increased with the stepwise addition of influencing factors and the resulting standard deviations ranged up to 30%. This study attempts to quantify experimentally observed intersubject variability of regional deposition fractions caused by individual variations of nasal and oral geometry, lung airway dimensions and breathing patterns in healthy lungs, serving as a baseline for subsequent calculations for diseased lungs, e.g. asthma, COPD, and emphysema, which may further increase intersubject variabilities of medically relevant depositions.