Thoracic malignant solitary fibrous tumors: A population-based study of survival Full Text
Journal of Thoracic Disease, 05/20/2011
Clinical Article
Milano MT et al. – From a population-based analysis of patients with thoracic malignant solitary fibrous tumors, stage and cancer-directed surgery had the greatest impact on OS and CSS. While being amenable to surgery likely reflects more indolent disease and/or better performance status and cardiopulmonary function, the significantly favorable impact of surgery also likely reflects a therapeutic benefit.
Methods- 82 patients with malignant solitary fibrous tumors of lung, pleura or mediastinum, diagnosed from 2001-2007
- Retrospectively analyzed using population-based Surveillance, Epidemiology, and End Results database
- Among 77 patients with available staging information, 42% (n=32) had localized disease, 31% (n=24) had regional disease extension (without nodal involvement) and 27% had regional-nodal (n=2) or distant (n=19) metastases
- Cancer-directed surgery performed in 85%; radiation performed in 16%
- 1-year, 5-year and median OS 87%, 49% and 4.6 years respectively
- 1-year, 5-year and median CSS 89%, 61% and 5.7 years respectively
- Less advanced stage and undergoing cancer-directed surgery were favorable prognostic factors
- For localized, regional and distant stage median OS was: not reached at 6.3 years, 4.4 years and 2.0 years respectively (P=0.021); median CSS not reached at 6.3 years, 5.0 years and 2.4 years (P=0.068)
- For patients undergoing versus not undergoing surgery, median OS 4.9 vs 0.9 years (P=0.053) and median CSS 5.7 vs 0.9 years (P=0.011)
- Tumor size not significant
