Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism Full Text
Investigational New Drugs, 03/11/2010
Hoyt MT et al. – The authors find that cribrostatin 6 treated cells have large amounts of reactive oxygen species (ROS) and, based on transcript profiling experiments and other data, this ROS generation is likely the primary mechanism by which cribrostatin 6 induces apoptosis. Given the success of certain ROS producers as anticancer agents, cribrostatin 6 has potential as a novel chemotherapeutic agent.