The effect of CyberKnife therapy on pulmonary function tests used for treating non-small cell lung cancer: a retrospective, observational cohort pilot study

Cancer Management and Research, 10/12/2012

Agarwal R et al. – The current standard for treating operable early stage non–small cell lung cancer is surgical resection and for inoperable cases it is external beam radiotherapy. Lung functions are adversely affected with both the above treatments. CyberKnife treatment limits radiation damage by tracking targets moving with each breath. The effect of CyberKnife treatment on pulmonary function tests has not been well documented. The authors observed that CyberKnife better preserves lung function status compared to current standards of care. It has shown to have very minimal side effects.


  • Lung cancer patients who underwent CyberKnife treatment and had pre- and post-treatment pulmonary function tests were included.
  • Paired t-tests were conducted.
  • The authors also conducted subgroup analysis.


  • Thirty-seven patients were included.
  • Median age was 73years.
  • No statistical difference between mean pre- and post-CyberKnife pulmonary function tests was found.

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