Renal function in patients with β-thalassaemia major: a long-term follow-up study

Nephrology Dialysis Transplantation, 06/14/2012

In most adults with thalassaemia major (TM), the estimated glomerular filtration rate (eGFR) tends to remain within a normal range after 10 years. However, patients with elevated phosphaturia, elevated uricuria and/or abnormal levels of calcaemia show a significant decline in eGFR over time, suggesting that tubular damage acquired in childhood caused by either TM or its treatment may eventually result in abnormal eGFR.

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