A clinicopathological and immunohistochemical study of gastric cancer with squamous cell carcinoma components: A clinically aggressive tumor

Journal of Digestive Diseases, 05/31/2012

Squamous cell carcinoma (SCC) components are derived from squamous metaplasia in a preexisting adenocarcinoma. Gastric adenocarcinoma with SCC components is associated with various patterns of metastasis, both SCC and adenocarcinoma components have the potential for metastasis. Gastric cancer with SCC components is a clinically aggressive tumor.

Methods

  • From January 2001 through June 2010, a total of 1735 patients underwent resection of gastric cancer.
  • Histopathologically, 8 patients were adenocarcinoma containing SCC components, in which the proportion of SCC components was above 25% of the total tumor mass in 4 patients.
  • The immunohistochemical and clinicopathological characteristics of these eight patients were analyzed.

Results

  • The median survival duration was 25 months.
  • Adenocarcinoma was present at the superficial layer of all tumors and SCC was primarily present at sites with deep invasion.
  • Immunohistochemically, adenocarcinoma components were positive for CAM5.2 and CK7 in all cases.
  • SCC components were positive for CEA and CK7 in more than 60% of cases.
  • Expression patterns of p53 product were identical in both components.
  • SCC components were positive for 34bE12, and adenocarcinoma components were negative for 34bE12 in all cases.

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