Acute Myeloid Leukemia and Myelodysplastic Syndromes After Radiation Therapy Are Similar to De Novo Disease and Differ From Other Therapy-Related Myeloid Neoplasms

Journal of Clinical Oncology, 05/17/2012

Acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) diagnosed in the past decade in patients after receiving XRT alone differ from therapy–related myeloid neoplasms (t–MN) occurring after chemotherapy/combined–modality therapy (C/CMT) and share genetic features and clinical behavior with de novo AML/MDS. The results suggest that post–external–beam radiation (XRT) MDS/AML may not represent a direct consequence of radiation toxicity and warrant a therapeutic approach similar to de novo disease.

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