The significance of low PU.1 expression in patients with acute promyelocytic leukemia

Journal of Hematology & Oncology, 05/14/2012

The results showed that PU.1 expression was lower in patients with APL than other acute myeloid leukemia (AML) subtypes and there was also a trend towards increasing PU.1 expression from AML–M0 to AML–M5, with the exception of AML–M3 (APL). These observations suggested that PU.1 expression was reduced by PML–RARalpha in APL patients.

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