Red and processed meat intake and risk of colorectal adenomas: A meta-analysis of observational studies
International Journal of Cancer, 05/04/2012
Xu X et al. – The summary RRs of CRA was 1.28 (95% CI: 1.03–1.60) for per 50 g/day increase in processed meat intake, and 1.17(95% CI: 1.08-1.26) for the highest vs the lowest level of processed meat intake.
Inconsistent results regarding the association between red and processed meat intake and the risk of colorectal adenoma (CRA), the precursor of colorectal cancer (CRC), have been reported. To provide a quantitative assessment of this association, we summarized the evidence from observational studies.
Relevant studies were identified in MEDLINE and EMBASE until December 31, 2011.
Summary relative risks (SRRs) with 95% confidence intervals (CIs) were pooled with a random-effects model.
A total of 21 studies (16 case-control studies and 5 cohort/nested case control studies) were included in this meta-analysis.
The SRRs of CRA were 1.36 (95% CI: 1.17–1.58) for every 100 g/day increase in red meat intake, and 1.24 (95% CI: 1.12-1.36) for the highest vs the lowest level of red meat intake.
Non-linear dose-response meta-analysis indicated that CRA risk increased approximately linearly with increasing intake of red meat up to approximately 90 g/day, where the curve reached its plateau.
Sub-grouped analyses revealed that the increased risk of CRA with intake of red meat was independent of geographic locations, design and confounders.
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