Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction

Cancer Causes and Control, 04/24/2012

Lin Y et al. – This population–based study indicates that a high dietary intake of lignans decreases the risk of adenocarcinoma of the esophagus and gastroesophageal junction.


  • A Swedish nationwide population-based case–control study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects.
  • Data on various exposures, including dietary data, were collected through personal interviews and questionnaires.
  • Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants.
  • Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors.


  • Participants in the highest quartile of intake of lignans compared with the lowest quartile were at a decreased risk of esophageal adenocarcinoma (OR, 0.65; 95 % CI, 0.38-1.12; p for trend=0.03), gastroesophageal junctional adenocarcinoma (OR, 0.37; 95 % CI, 0.23-0.58; p for trend<0.0001), and these adenocarcinomas combined (OR, 0.45; 95 % CI, 0.31-0.67; p for trend<0.0001).
  • No clear associations were found between lignan intake and risk of esophageal squamous cell carcinoma.

Print Article Summary Cat 2 CME Report