Fruit and vegetable intake and the risk of gastric adenocarcinoma

International Journal of Cancer, 04/19/2012

Gonzalez CA et al. – The inverse association between fresh fruit and citrus fruits and risk of gastric cancer (GC) seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC respectively.

Methods

  • Subjects are 477,312 men and women mostly aged 35 to 70years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11years of follow-up.
  • Information on diet and lifestyle was collected at baseline.
  • A calibration study in a sub-sample was used to correct for dietary measurement errors.

Results

  • Comparing the highest vs lowest quintile of intake, the authors found an inverse association between total intake of V&F and GC risk (HR 0.77; 95% CI 0.57-1.04; p for trend 0.02), between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.36-0.97; p for trend 0.03), and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.38-1.00, p for trend 0.01).
  • Although calibration revealed somewhat stronger inverse associations none of the risks reached statistical significance.
  • There was no association between total or specific vegetables intake and GC risk.

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