Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

Annals of Hematology, 04/13/2012

Thol F et al - A high MN1, ERG, BAALC, and EVI1 (MEBE) expression score is an unfavorable prognostic marker in myelodysplastic syndromes (MDS) and is associated with an increased risk for progression to acute myeloid leukemia (AML). Expression of the MEBE genes is regulated by FLI1 and c–MYC, which are potential upstream targets of the MEBE signature.

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