Iron Deficiency Anemia Prevalence at First Stroke or Transient Ischemic Attack
The Canadian Journal of Neurological Sciences, 03/02/2012Dubyk MD et al.
These findings support the initiation of a prospective case control study to investigate iron deficiency anemia (IDA) as a risk factor for ischemic stroke in elderly patients.
Ninety-four patients were enrolled.
An algorithm containing values for hemoglobin, ferritin, total iron binding capacity, transferrin saturation, and serum transferrin receptor measured at admission was used to identify IDA.
Usual dietary intake was assessed with the Clue II food frequency questionnaire.
Prevalence estimates were 6.4% for IDA, 2.1% for iron deficiency without anemia, and 6.4% for anemia from other causes.
IDA prevalence was significantly higher than published National Health and Nutrition Examination Survey III (NHANES III) estimates for gender-specific age groups ≤70 years (One-Sample Proportion Test; males p = 0.038 [n= 37]; females p = 0.002 [n=44]).
A comparison of IDA prevalence against selected controls from the NHANES III database yielded an odds ratio (OR) of 6.3, 95% confidence interval (CI) 0.8 to 53.7, which was not statistically significant (Fisher's Exact Test; n=94; p = 0.118).
Multivariate linear regression analysis of dietary intake with indicators of iron status (n=58) revealed only iron supplements (p = 0.013) and heme iron intake (p = 0.038) as negative predictors of total iron binding capacity (p<0.05).
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