Comparison of adiponectin concentration between pancreatic cancer and colorectal cancer
Journal of Gastrointestinal Oncology, 10/03/2011
Phelip JM et al.
– ADP concentration is higher in PC patients than in CRC patients. ADP concentration > 10 microgram/l was independently associated with pancreatic cancer. These data confirm that adiponectin rates differ strongly according to the type of cancer.
Included all the incident cases of PC gathered from a university hospital in France from January 2006 till September 2007
Control population of incident cases of colorectal cancer (CRC), matching or age, gender, and tumor staging was set in same period
In addition to demographic data, the other parameters analyzed were: ADP rate, insulinoresistance (Homa-test), presence of a dysmetabolic syndrome, evolution of weight and data concerning the tumor (staging, tumor markers: ACE, CA19.9)
33 CRC and 53 PC were analyzed. Type 2 diabetes was found in 18.2% of the CRC cases and 39.6% of the PC (p = 0.037)
Mean ADP level significantly higher in PC versus CRC (20.9 microgram/l versus 15.9 microgram/l; p = 0.03)
In multivariate analysis , after adjusting for gender, age, bilirubinemia and weigth loss, the variables independently associated with a high level of ADP (> 10 microG/L) were type 2 diabetes (OR = 0.05, p = 0.01), insulinoresistance (OR = 0.42, p = 0.05) and PC (OR = 12.03, p = 0.047)
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