Costs of early adjuvant radiation therapy after radical prostatectomy: A decision analysis
Annals of Oncology, 07/06/2011
Showalter TN et al.
– ART appears cost effective compared with observation based upon this decision analysis model. Future research should consider more costly radiation therapy (RT) approaches, such as intensity-modulated RT, and should evaluate the cost-effectiveness of ART versus early salvage RT.
Decision analysis model designed to compare ART versus observation over 10-year time horizon
Probabilities of treatment success, utilization of salvage treatments, and rates of adverse events were taken from published results of SWOG 8794
Cost inputs were based on 2010 Medicare reimbursement rates
Primary outcome measure was incremental cost per prostate-specific antigen (PSA) success (i.e. serum PSA level <0.4 ng/ml)
ART results in a higher PSA success rate than observation with probability of 0.43 versus 0.22
Mean incremental cost per patient for ART versus observation was $6023
Mean incremental cost-effectiveness ratio $26,983 over 10-year period
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