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Loss of heterozygosity of the Mutated in Colorectal Cancer gene is not associated with promoter methylation in non-small cell lung cancer

Poursoltan P et al. – The authors have shown that promoter methylation of the APC gene does not extend to the neighbouring Mutated in Colorectal Cancer’ (MCC) gene in lung cancer, but LOH is found at both loci. The variable levels of MCC expression were not associated with promoter methylation and may be regulated through other cellular mechanisms. [more...]