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Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors

Jezequel P et al. – Validation step by means of immunohistochemistry (IHC) and immunoassay (IA) confirmed the prognostic value of FTL level. CD68 IHC showed thatFerritin light chain (FTL) was stored in tumor–associated macrophages (TAM), which exhibit an M2–like phenotype. The authors report here, first, the validation of FTL as a breast tumor prognostic biomarker in node–negative patients, and second, the fact that FTL is stored in TAM. [more...]

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