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Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival
Schultz CR et al. – The authors conclude that inhibition of HSP27 alone, or in combination with pAKT inhibitor IV, may be an effective therapeutic approach to inhibit SPARC–induced glioma cell invasion and survival in SPARC–positive/PTEN–wildtype and SPARC–positive/PTEN–null tumors, respectively. [more...]
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