Impact of lower urinary tract symptoms on prostate cancer risk among Japanese men with prostate-specific antigen <10 ng/mL and non-suspicious digital rectal examination
International Journal of Urology, March 25, 2013
Ito M et al. - This study aimed to investigate the association between lower urinary tract symptoms status and prostate cancer risk at initial extended biopsy. In men with elevated prostate-specific antigen, absent or mild lower urinary tract symptoms are positively associated with prostate cancer and high-grade disease regardless of the prostate volume. This finding is especially useful in men with enlarged prostates. Methods Between 2005 and 2011, the International ...
Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies
The Journal of Urology, April 17, 2013
Helfand BT et al. - Authors determined how many men would continue to meet common biopsy criteria after genetic correction of their measured prostate specific antigen concentrations. These results suggest that 4 single nucleotide polymorphisms can be used to adjust a man's measured prostate specific antigen concentration and potentially delay or prevent unnecessary prostate biopsies in Caucasian men. Methods The genotypes of 4 single nucleotide polymorphisms previously ...
Prospective multicenter evaluation of the beckman coulter prostate health index using WHO calibration
The Journal of Urology, April 17, 2013
Loeb S et al. - Authors studied the influence of assay standardization on these markers. The prostate Health Index can be calculated using Hybritech or WHO standardized assays. It significantly improved prediction of the biopsy outcome over that of percent free or prostate specific antigen alone. Methods prostate specific antigen, percent free prostate specific antigen and [–2]proPSA were measured using Hybritech calibration in 892 men from a prospective, multicenter study ...
Prostate HistoScanning: A screening tool for prostate cancer?
International Journal of Urology, April 22, 2013
De Coninck V et al. - This study aimed to evaluate prostate HistoScanning as a screening tool for prostate cancer in a pilot study. These findings suggest that prostate HistoScanning might be helpful for the selection of patients in whom prostate biopsies are necessary. This imaging technique can be used to direct biopsies in specific regions of the prostate with a higher cancer detection rate. Methods During a 6-month period, 94 men with normal or suspicious digital rectal ...
Operational characteristics of 11c-choline positron emission tomography/computerized tomography for prostate cancer with biochemical recurrence after initial treatment
The Journal of Urology, April 5, 2013
Mitchell CR et al. - Authors examined the performance of 11 C-choline positron emission tomography/computerized tomography for its ability to delineate prostate cancer distribution and extent after initial therapy. 11 C-choline positron emission tomography/computerized tomography performs well in men with biochemical recurrence after primary treatment failure. The optimal prostate specific antigen value for lesion detection is approximately 2.0 ng/ml. They found that 11 ...
Do racial disparities exist in the use of prostate cancer screening and detection tools in veterans?
Urologic Oncology: Seminars and Original Investigations, March 20, 2013
Hudson MA et al. - This study aimed to determine whether racial disparities exist in the use of prostate cancer screening and detection tools in veterans. Among regular users of the VHA for healthcare, no disparities toward AA veterans exist in the use of prostate cancer screening and detection tools. Any differences in prostate cancer treatment outcomes are not likely because of inequalities in the use of prostate cancer screening or detection tools. Methods Administrative ...
The impact of prostate volume, number of biopsy cores and American urological association symptom score on the sensitivity of cancer detection using the prostate cancer prevention trial risk calculator
The Journal of Urology, June 13, 2013
Ankerst DP et al. - Authors assessed the independent predictive value of prostate volume, number of biopsy cores and AUASS (American Urological Association symptom score) compared to risk factors included in the PCPTRC (prostate Cancer Prevention Trial risk calculator for prostate cancer) and PCPTHG (prostate Cancer Prevention Trial risk calculator for high grade cancer [Gleason grade 7 or greater]). Adjusted PCPT risk calculators for volume, number of cores and AUASS improve cancer ...
Prostate cancer screening and the management of clinically localized disease
BMC Medicine, March 4, 2013
Wilt T.J.-This review update a previous review, highlighting new findings that deal with clinical questions and future research needs for the prevention, detection, and treatment of clinically localized prostate cancer. prostate cancer is an important health problem. More than 40?000 incident cases of prostate cancer and more than 10?000 prostate cancer related deaths occur each year in the United Kingdom. Prevention, detection, and treatment of localized prostate cancer ...
Low serum testosterone levels are predictive of prostate cancer
World Journal of Urology, April 9, 2013
Mearini L et al. - Aims of present study were to assess whether testosterone and serum sex hormone levels are predictors of benign prostatic hyperplasia (BPH) or prostate cancer (PC) and to verify whether prostate cancer is associated with low testosterone levels, and to test association between testosterone levels and known prognostic factors in prostate cancer. This study supports experimental findings that testosterone levels are predictor of prostate cancer and that prostate cancer ...
1.5-t magnetic resonance-guided transgluteal biopsies of the prostate in patients with clinically suspected prostate cancer: technique and feasibility
Investigative Radiology, May 14, 2013
Bodelle B et al. - The aim of this study was to examine the feasibility and safety of magnetic resonance–guided prostate biopsy (MRGBx) with a transgluteal approach in patients with cancer suspicious prostatic lesions. Magnetic resonance–guided prostate biopsy of the prostate gland with a transgluteal approach is feasible, safe, and a promising technique for histological clarification of cancer suspicious lesions in patients with increased prostate-specific antigen levels after ...