Identifying serum biomarkers for ovarian cancer by screening with surface-enhanced laser desorption/ionization mass spectrometry and the artificial neural network
International Journal of Gynecological Cancer, May 3, 2013
Yang J et al. - The purpose of this study was to screen potential serum tumor biomarkers for the diagnosis of ovarian cancer. The proteins represented by these 3 peaks are biomarker candidates for ovarian cancer diagnosis and/or monitoring treatment response.
The study includes 3 sets.
The first set of patients included 37 ovarian cancers and 31 healthy women (healthy controls).
The second set included 42 ovarian cancers, 33 patients with benign ovarian tumor, ...
Predictors of ovarian response in women treated with corifollitropin alfa for in vitro fertilization/intracytoplasmic sperm injection
Fertility and Sterility, May 17, 2013
Polyzos NP et al. - This study aimed to identify predictors of ovarian response in women undergoing ovarian stimulation with corifollitropin alfa in a GnRH antagonist protocol and determine specific thresholds for the prediction of low and excessive responders. AMH and AFC are the best predictors for low and excessive response in women treated with corifollitropin alfa in an antagonist protocol. Using AMH and AFC to select suitable candidates for treatment with corifollitropin alfa may ...
Diabetes mellitus and ovarian cancer risk: a systematic review and meta-analysis of observational studies
International Journal of Gynecological Cancer, March 6, 2013
Lee JY et al. - The objective of this study was to evaluate the epidemiologic association between diabetes and risk of ovarian cancer. This study suggests that women with diabetes have a moderately increased risk of ovarian cancer.
Authors searched PubMed, EMBASE, and The Cochrane Library for observational studies on the association between diabetes and ovarian cancer.
Cohort studies that reported relative risks (RRs) and case-control studies that showed ...
Accuracy of Positron Emission Tomography/Computed Tomography in the Diagnosis and Restaging for Recurrent Ovarian Cancer: A Meta-Analysis
International Journal of Gynecological Cancer, April 29, 2013
Limei Z. et al.- A meta-analysis was performed to estimate the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) in suspected recurrent ovarian cancer. It was seen that Positron emission tomography/computed tomography is a useful tool for predicting the diagnosis and restaging of suspected recurrent ovarian carcinoma.
PubMed, The Cochrane Library, Embase, and Web of Science were systematically searched.
Studies that compared ...
Imbalance in serum soluble CD30/CD30L and CD40/CD40L systems are associated with ovarian tumors
Human Immunology, February 18, 2013
Mielczarek-Palacz A et al. - The aim of the study was to examine the concentrations of the soluble receptors and their ligands of CD30/CD30L and CD40/CD40L systems in the serum of women with ovarian tumor and in the ovarian cyst fluid of women with Cystadenoma serosum. Measurement of studied parameter concentrations in serum of women with ovarian tumors has been suggested to be a potential tool in monitoring of inflammatory. Evaluation of sCD30, sCD30L and sCD40 might be an early ...
Reduced expression of NDUFS3 and its clinical significance in serous ovarian cancer
International Journal of Gynecological Cancer, May 2, 2013
Wang P et al. - This study evaluates NDUFS3 expression and its clinical significance in human serous ovarian adenocarcinoma. NDUFS3 expression is down-regulated in serous ovarian adenocarcinoma, suggesting that NDUFS3 may contribute to the development of serous ovarian cancer. Methods 30 ovarian normal epithelium, 30 benign serous adenoma, and 100 serous carcinoma tissues were collected, and the expression of NDUFS3 protein and messenger RNA was evaluated by ...
Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count
European Journal of Obstetrics & Gynecology and Reproductive Biology, May 6, 2013
Yilmaz N et al. - This study aimed to evaluate the effect of dehydroepiandrosterone (DHEA) supplementation on ovarian reserve by measuring markers such as antral follicle count, serum anti-Müllerian hormone (AMH) and inhibin B in patients with diminished ovarian reserve. DHEA supplementation is an effective option for patients with diminished ovarian reserve. Prior to assisted reproductive technology, patients with diminished ovarian reserve should be offered DHEA supplementation ...
Tubal ligation, hysterectomy, and epithelial ovarian cancer in the New England case-control study
International Journal of Cancer, May 7, 2013
Rice MS et al. - tubal ligation and hysterectomy with unilateral oophorectomy were inversely associated with ovarian cancer risk in a large population-based case-control study. Methods We used logistic regression to examine tubal ligation, simple hysterectomy, and hysterectomy with unilateral oophorectomy in relation to risk of epithelial ovarian cancer in the New England Case-Control study. Our primary analysis included 2,265 cases and 2,333 controls. Results Overall, ...
Preserved foods associated with increased risk of ovarian cancer
Gynecologic Oncology, May 14, 2013
Lee AH et al. - This study aims to investigate the association between consumption of preserved foods and risk of epithelial ovarian cancer in southern Chinese women. Intake of preserved foods was positively associated with the incidence of epithelial ovarian cancer in southern Chinese women. Methods A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, from 2006 to 2008. Participants were 500 incident epithelial ovarian cancer ...
Apolipoprotein concentrations are elevated in malignant ovarian cyst fluids suggesting that lipoprotein metabolism is dysregulated in epithelial ovarian cancer
Cancer Investigation, May 22, 2013
Podzielinski I et al. - SELDI-TOF MS analysis of ovarian cyst fluids revealed that peaks m/z 8696 and 8825 discriminate malignant, borderline, and benign tumors. The data suggest that lipoprotein metabolism is dysregulated in ovarian cancer and that apoA2 and apoE warrant further investigation as ovarian tumor biomarkers.