Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest symptoms, treatments, risk factors, and clinical trials in Cancer and Hematology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

2 A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy na├»ve castration-resistant prostate cancer Investigational New Drugs, July 25, 2014    Clinical Article

3 Randomized phase II trial of sorafenib alone or in combination with carboplatin/paclitaxel in women with recurrent platinum sensitive epithelial ovarian, peritoneal, or fallopian tube cancer Investigational New Drugs, July 25, 2014    Clinical Article

4 Clinical activity of enzalutamide versus docetaxel in men with castration-resistant prostate cancer progressing after abiraterone The Prostate, July 25, 2014    Clinical Article

5 Foreign vs. US born patients and the association of type I uterine cancer American Journal of Obstetrics and Gynecology, July 25, 2014    Clinical Article

6 RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase Breast Cancer Research and Treatment, July 25, 2014    Clinical Article

7 Upper limit of cancer extent on biopsy defining very low risk prostate cancer BJU International, July 25, 2014    Clinical Article

8 Interim FDG PET/CT for predicting the outcome in patients with head and neck cancer The Laryngoscope, July 25, 2014    Clinical Article

9 The economics of bladder cancer: Costs and considerations of caring for this disease Full Text European Urology, July 25, 2014    Review Article

10 Serum MicroRNA-210 as a predictive biomarker for treatment response and prognosis in patients with hepatocellular carcinoma undergoing transarterial chemoembolization Journal of Vascular and Interventional Radiology, July 25, 2014    Clinical Article

11 Cutaneous adverse events in patients treated with BRAF inhibitor based therapies for metastatic melanoma for longer than 52 weeks. British Journal of Dermatology, July 25, 2014    Clinical Article

12 Exosome-derived miRNAs and ovarian carcinoma progression Carcinogenesis, July 25, 2014    Clinical Article

13 Caught in the cross fire: p53 in inflammation Carcinogenesis, July 25, 2014    Clinical Article

14 The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients The American Journal of Surgery, July 25, 2014    Clinical Article

15 SUMOylation of the ING1b tumor suppressor regulates gene transcription Carcinogenesis, July 25, 2014    Clinical Article

16 Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features Carcinogenesis, July 25, 2014    Clinical Article

17 Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα Carcinogenesis, July 25, 2014    Clinical Article

18 MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1 Carcinogenesis, July 25, 2014    Clinical Article

19 Differences in maximum tolerated doses and approval doses of molecularly targeted oncology drug between Japan and Western countries Investigational New Drugs, July 25, 2014    Clinical Article
Exclusive Author Commentary

20 A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors Investigational New Drugs, July 25, 2014    Clinical Article

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Clinical Pearls in Oncology

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Highlights in Oncology

YKL-40 predicts poor prognosis for bladder cancer

As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).

Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas

As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.

Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma

As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.

Other Topics in Oncology

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