1Efficacy of physical examination, ultrasound, and ultrasound combined with fine-needle aspiration for axilla staging of primary breast cancerBreast Cancer Research and Treatment  Clinical Article
2FDA approval: siltuximab for the treatment of patients with multicentric castleman diseaseClinical Cancer Research  Clinical Article
3Alzheimer disease and cancer risk: A meta-analysisJournal of Cancer Research & Clinical Oncology  Evidence Based Medicine
4High expression of Hsp90β is associated with poor survival in resectable non-small cell lung cancer patientsHistopathology  Clinical Article
5Differential expression of cancer-associated fibroblast-related proteins according to molecular subtype and stromal histology in breast cancerBreast Cancer Research and Treatment  Clinical Article
6Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cellsBreast Cancer Research and Treatment  Clinical Article
7Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2'-deoxycytidine in human breast cancer cellsBreast Cancer Research and Treatment  Clinical Article
8DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cellsBreast Cancer Research and Treatment  Clinical Article
9TOOKAD Soluble focal therapy: Pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancerWorld Journal of Urology  Clinical Article
10Open-label, 9-month extension study investigating the uro-selective alpha-blocker silodosin in men with LUTS associated with BPHWorld Journal of Urology  Clinical Article
1Investigational therapy could attack cause of sickle cell crisesDuke Medicine
2Rutgers Cancer Institute of New Jersey advances understanding of surgical treatment options for genitourinary cancersRutgers Cancer Institute of New Jersey News
3Reducing tumor growthHarvard Medical School News
4On time, on target - A novel tool could help personalize cancer treatmentsHarvard Medical School News
5Interaction of estrogen receptor and coactivators seen for first timeBaylor College of Medicine News
6Massey research leads to multi-institutional phase 1 clinical trial for aggressive lymphomasVirginia Commonwealth University News
7Use of new systemic adjuvant therapy in gastrointestinal tumors (GITSs) increasing, leading to better survivalAmerican Cancer Society News
8Researchers detail reasons for ibrutinib therapy discontinuation in chronic lymphocytic leukemiaThe Ohio State University Wexner Medical Center
9Black men less willing to be investigated for prostate cancerUniversity of Exeter Medical School
10Leukaemia-associated mutations almost inevitable as we ageWellcome Trust Sanger Institute News

Show Me:

CHD7 associated with survival in pancreatic ductal adenocarcinoma patients receiving gemcitabine

As reported in Cancer Research, low CHD7 expression is associated with increased RFS and OS in pancreatic ductal adenocarcinoma patients receiving gemcitabine. There was no association between CHD7 expression and RFS or OS in patients who were not treated with gemcitabine.

VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma

As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.

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Clinical Pearl from Smartest DocAll IPMNs are considered premalignant lesions with malignant potential.

Clinical Pearl from Smartest DocTestosterone-based treatments may prevent the development of breast cancer in pre- and postmenopausal women.

Clinical Pearl from Smartest DocAge, diabetes mellitus, and tumor stage are independent prognostic factors for patients with adenoid cystic carcinoma of the head and neck.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List