Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial The Lancet Oncology, October 20, 2014    Clinical Article

2 Oral rivaroxaban versus enoxaparin with vitamin K antagonist for the treatment of symptomatic venous thromboembolism in patients with cancer (EINSTEIN-DVT and EINSTEIN-PE): A pooled subgroup analysis of two randomised controlled trials The Lancet Haematology, October 20, 2014    Clinical Article

3 Phase I study of 30-minute infusion of carfilzomib as single agent or in combination with low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma Journal of Clinical Oncology, October 20, 2014    Clinical Article

4 Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12 Journal of Clinical Oncology, October 20, 2014    Clinical Article

5 Exercise and risk of major cardiovascular events in adult survivors of childhood Hodgkin lymphoma: a report from the childhood cancer survivor study Journal of Clinical Oncology, October 20, 2014    Clinical Article

6 Differences in time to disease progression do not predict for cancer-specific survival in patients receiving immediate or deferred androgen-deprivation therapy for prostate cancer: Final results of EORTC randomized trial 30891 with 12 years of follow-up Full Text European Urology, October 20, 2014    Clinical Article

7 Is there any prognostic impact of intraductal carcinoma of prostate in initial diagnosed aggressively metastatic prostate cancer? The Prostate, October 20, 2014    Clinical Article

8 HPV and lung cancer risk: A meta-analysis Journal of Clinical Virology, October 20, 2014    Evidence Based Medicine

9 Lapatinib-associated mucocutaneous toxicities are clinical predictors of improved progression-free survival in patients with human epidermal growth factor receptor (HER2)-positive advanced breast cancer Breast Cancer Research and Treatment, October 20, 2014    Clinical Article

10 Combined use of endometrial sample and magnetic resonance imaging in the preoperative risk-stratification of endometrial carcinomas Acta Obstetricia et Gynecologica Scandinavica, October 20, 2014    Clinical Article

11 Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma Clinical Cancer Research, October 20, 2014    Clinical Article

12 Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: Novel therapeutic strategy for aggressive breast cancers Molecular Cancer Therapeutics, October 20, 2014    Clinical Article

13 A phase I, dose-escalation study of the multi-targeted receptor tyrosine kinase inhibitor, golvatinib, in patients with advanced solid tumors Clinical Cancer Research, October 20, 2014    Clinical Article

14 Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis Neuro-Oncology, October 20, 2014    Clinical Article

15 NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate to post-induction residual disease Clinical Cancer Research, October 20, 2014    Clinical Article

16 Cancer-related inflammation and treatment effectiveness The Lancet Oncology, October 20, 2014    Review Article

17 Ramucirumab: Successfully targeting angiogenesis in gastric cancer Clinical Cancer Research, October 20, 2014    Clinical Article

18 Antibody against granulin-epithelin precursor sensitizes hepatocellular carcinoma to chemotherapeutic agents Molecular Cancer Therapeutics, October 20, 2014    Clinical Article

19 High dose interleukin-2 (Aldesleukin) - expert consensus on best management practices-2014 Full Text Journal for ImmunoTherapy of Cancer, October 20, 2014    Review Article    Clinical Guideline

20 Combination therapy for KIT-mutant mast cells: Targeting constitutive NFAT and KIT activity Molecular Cancer Therapeutics, October 20, 2014    Clinical Article

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Clinical Pearls in Oncology

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Highlights in Oncology

CHD7 associated with survival in pancreatic ductal adenocarcinoma patients receiving gemcitabine

As reported in Cancer Research, low CHD7 expression is associated with increased RFS and OS in pancreatic ductal adenocarcinoma patients receiving gemcitabine. There was no association between CHD7 expression and RFS or OS in patients who were not treated with gemcitabine.

Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma

As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.

Immunophenotype of small intestinal adenocarcinoma predicts survival

As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.


Other Topics in Oncology

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