We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1IgE and risk of cancer in 37 747 individuals from the general populationAnnals of Oncology, May 27, 2015  Clinical Article
2Vitamin D and pancreatic cancer: a pooled analysis from the pancreatic cancer case-control consortiumAnnals of Oncology, May 27, 2015  Clinical Article
3The relationship between Glasgow prognostic score and serum tumor markers in patients with advanced non-small cell lung cancerBMC Cancer, May 27, 2015  Full Text  Clinical Article
4Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancerBMC Cancer, May 27, 2015  Full Text  Clinical Article
5A phase II trial to assess the activity of gemcitabine and docetaxel as first line chemotherapy treatment in patients with unresectable leiomyosarcomaClinical Sarcoma Research, May 27, 2015  Full Text  Clinical Article
6Natural history and outcomes in localised immunoglobulin light-chain amyloidosis: a long-term observational studyThe Lancet Haematology, May 27, 2015  Clinical Article
7High-throughput somatic mutation profiling in pulmonary sarcomatoid carcinomas using the LungCarta Panel: exploring therapeutic targetsAnnals of Oncology, May 27, 2015  Clinical Article
8Long-term ovarian function in women treated with CHOP or CHOP plus etoposide for aggressive lymphomaAnnals of Oncology, May 27, 2015  Clinical Article
9Fentanyl buccal tablet: A new breakthrough pain medication in early management of severe vaso-occlusive crisis in sickle cell diseasePain Practice, May 27, 2015  Clinical Article
10A ranking-based meta-analysis reveals let-7 family as a meta-signature for grade classification in breast cancerPLOS ONE, May 27, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Research: Daily aspirin could block growth of breast, other cancersU.S. Department of Veterans Affairs Research News, May 27, 2015
2Study shows more pediatric patients being treated with proton therapyScripps Health, May 27, 2015
3Using healthy skin to identify cancers originsWellcome Trust Sanger Institute News, May 27, 2015
4New genomics tool could help predict tumor aggressiveness, treatment outcomesThe OSUCCC–James, May 27, 2015
5Ovarian cancer-specific markers set the stage for early diagnosis, personalized treatmentsUC San Diego Health System, May 27, 2015
6Discovery of biomarker offers hope for brain cancer patientsUNSW Australia Health News, May 27, 2015
7Catching lung cancer earlyBoston University School of Medicine, May 26, 2015
8Massey researcher leads task force to develop first guidelines for pediatric thyroid cancerVirginia Commonwealth University News, May 26, 2015
9Body's 'serial killers' captured on film destroying cancer cellsUniversity of Cambridge News, May 26, 2015
10What drives advanced prostate cancer? New study describes genomic landscapeUniversity of Michigan Health System, May 26, 2015

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Immunophenotype of small intestinal adenocarcinoma predicts survival

As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.

CHD7 associated with survival in pancreatic ductal adenocarcinoma patients receiving gemcitabine

As reported in Cancer Research, low CHD7 expression is associated with increased RFS and OS in pancreatic ductal adenocarcinoma patients receiving gemcitabine. There was no association between CHD7 expression and RFS or OS in patients who were not treated with gemcitabine.

YKL-40 predicts poor prognosis for bladder cancer

As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).

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Clinical Pearls

Clinical Pearl from Smartest DocIGF-1R is not a likely candidate for therapeutic inhibition in Ewing sarcoma.

Clinical Pearl from Smartest DocResistance to EGFR TKIs typically emerges after 9-12 months in patients with NSCLC

Clinical Pearl from Smartest DocApproximately 25% of patients with head and neck mucoepidermoid carcinoma have second primary malignancies.

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