Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Everolimus plus exemestane for hormone-receptor–positive, human epidermal growth factor receptor-2–negative advanced breast cancer: Overall survival results from BOLERO-2 Annals of Oncology, September 30, 2014    Clinical Article

2 First FDA approval of neoadjuvant therapy for breast cancer: Pertuzumab for the treatment of patients with HER2-positive breast cancer Clinical Cancer Research, September 30, 2014    Clinical Article

3 Nonsteroidal anti-inflammatory drugs and the risk of Barrett's esophagus Clinical Gastroenterology and Hepatology , September 30, 2014    Clinical Article

4 Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern Cooperative Oncology Group Trial E3303 Clinical Cancer Research, September 30, 2014    Clinical Article

5 Phase II study of perifosine and sorafenib dual-targeted therapy in patients with relapsed or refractory lymphoproliferative diseases Clinical Cancer Research, September 30, 2014    Clinical Article

6 Sexually transmitted infections and prostate cancer risk: A systematic review and meta-analysis Cancer Epidemiology, September 30, 2014    Review Article

7 Metabolic syndrome factors and risk of postoperative depression in high-grade glioma patients in a 1.5-year prospective study Medical Oncology, September 30, 2014    Clinical Article

8 Prognostic impact of definitive local therapy of the primary tumor in men with metastatic prostate cancer at diagnosis: A population-based, propensity score analysis Cancer Epidemiology, September 30, 2014    Clinical Article

9 Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma Full Text World Journal of Gastroenterology, September 30, 2014    Clinical Article

10 Glucocorticoid prescriptions and breast cancer recurrence: A Danish nationwide prospective cohort study Annals of Oncology, September 30, 2014    Clinical Article

11 Increased nuclear factor erythroid 2-related factor 2 expression predicts worse prognosis of prostate cancer patients treated with radical prostatectomy Human Pathology, September 30, 2014    Clinical Article

12 Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy: Frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system Human Pathology, September 30, 2014    Clinical Article

13 Five year prostate-specific antigen outcomes after caesium prostate brachytherapy Clinical Oncology, September 30, 2014    Clinical Article

14 Prognostic factors for brain metastases from non-small cell lung cancer with EGFR mutation: Influence of stable extracranial disease and erlotinib therapy Medical Oncology, September 30, 2014    Clinical Article

15 Dexmedetomidine and hydromorphone: A novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children Pediatric Blood & Cancer, September 30, 2014    Clinical Article

16 Growth plate abnormalities in pediatric cancer patients undergoing phase 1 anti-angiogenic therapy: A report from the children's oncology group phase I consortium Pediatric Blood & Cancer, September 30, 2014    Clinical Article

17 The latest progress in research on triple negative breast cancer (TNBC): Risk factors, possible therapeutic targets and prognostic markers Full Text Journal of Thoracic Disease, September 30, 2014    Review Article

18 Prognostic information of a previously diagnosed sister is an independent prognosticator for a newly diagnosed sister with breast cancer Annals of Oncology, September 30, 2014    Clinical Article

19 Chronic natural killer lymphoproliferative disorders: characteristics of an international cohort of 70 patients Annals of Oncology, September 30, 2014    Clinical Article

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Clinical Pearls in Oncology

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Highlights in Oncology

CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).

Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma

As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.

Immunophenotype of small intestinal adenocarcinoma predicts survival

As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.

Other Topics in Oncology

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