Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest symptoms, treatments, risk factors, and clinical trials in Cancer and Hematology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Plasma insulin, C-peptide, and blood glucose and the risk of gastric cancer: The Japan Public Health Center–based Prospective Study International Journal of Cancer, July 30, 2014    Clinical Article

2 Non–small-cell lung cancer after breast cancer: A population-based study of clinicopathologic characteristics and survival outcomes in 3529 women Journal of Thoracic Oncology, July 30, 2014    Clinical Article

3 CD63 tetraspanin is a negative driver of epithelial-to-mesenchymal transition in human melanoma cells Journal of Investigative Dermatology, July 30, 2014    Clinical Article

4 Increased survival in hepatocellular carcinoma with iodine-125 implantation plus radiofrequency ablation Journal of Hepatology, July 30, 2014    Clinical Article

5 Motesanib plus carboplatin/paclitaxel in patients with advanced squamous non–small-cell lung cancer: Results from the randomized controlled MONET1 study Journal of Thoracic Oncology, July 30, 2014    Clinical Article

6 A phase II, open-label, multicenter study to evaluate the antitumor efficacy of CO-1.01 as second-line therapy for gemcitabine-refractory patients with stage IV pancreatic adenocarcinoma and negative tumor hENT1 expression Pancreatology, July 30, 2014    Clinical Article

7 A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype Breast Cancer Research, July 30, 2014    Clinical Article

8 Clinical staging of patients with early esophageal adenocarcinoma: Does FDG-PET/CT have a role Journal of Thoracic Oncology, July 30, 2014    Clinical Article

9 Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival, and invasiveness of breast cancer stem cells Breast Cancer Research, July 30, 2014    Clinical Article

10 Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients Leukemia, July 30, 2014    Clinical Article

11 The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting Leukemia, July 30, 2014    Clinical Article

12 Phospho-flow detection of constitutive and cytokine-induced pSTAT3/5, pAKT and pERK expression highlights novel prognostic biomarkers for patients with multiple myeloma Leukemia, July 30, 2014    Clinical Article

13 Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients Thrombosis Research, July 30, 2014    Clinical Article

14 The impact of oxaliplatin-based chemotherapy for colorectal cancer on the autonomous nervous system European Journal of Neurology, July 30, 2014    Clinical Article

15 Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression Breast Cancer Research, July 30, 2014    Clinical Article

16 Assessment of improved organ at risk sparing for meningioma: Light ion beam therapy as boost versus sole treatment option Radiotherapy & Oncology, July 30, 2014    Clinical Article

17 The origins of radiotherapy: Discovery of biological effects of X-rays by Freund in 1897, Kienbock's crucial experiments in 1900, and still it is the dose Radiotherapy & Oncology, July 30, 2014    Clinical Article

18 Main duct intraductal papillary mucinous neoplasm presenting as a duodenal mass Gastrointestinal Endoscopy, July 30, 2014    Clinical Article

19 Endoscopic quality indicators for esophagogastroduodenoscopy in gastric cancer screening Digestive Diseases and Sciences, July 30, 2014    Clinical Article

20 No pharmacokinetic alteration of docetaxel following coadministration of aprepitant 3 h before docetaxel infusion Cancer Chemotherapy and Pharmacology, July 30, 2014    Clinical Article

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Clinical Pearls in Oncology

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Highlights in Oncology

CHD7 associated with survival in pancreatic ductal adenocarcinoma patients receiving gemcitabine

As reported in Cancer Research, low CHD7 expression is associated with increased RFS and OS in pancreatic ductal adenocarcinoma patients receiving gemcitabine. There was no association between CHD7 expression and RFS or OS in patients who were not treated with gemcitabine.

Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma

As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.

Increased incidence of second primary cancers in patients with salivary gland tumors

As reported in JAMA—Otolaryngology-Head & Neck Surgery, patients with salivary gland tumors have an increased risk of second primary tumors and newly developed cancers. Specifically, the cumulative 2-, 5-, and 10-year rates for second primary cancers are 4.4%, 8.3%, and 12.4%, respectively. Similarly, the cumulative 2-, 5-, and 10-year rates for newly diagnosed cancers are 1.1%, 3.4%, and 10.5%, respectively.

Other Topics in Oncology

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