The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.
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1 A meta-analysis on the impact of platinum-based adjuvant treatment on the outcome of borderline ovarian tumors with invasive implants Full Text The Oncologist, January 28, 2015 Clinical Article
2 Predictive value of biopsy specimens suspicious for melanoma: Support for 6-mm criterion in the ABCD rule Journal of the American Academy of Dermatology, January 28, 2015 Clinical Article
3 Clinical significance of thrombocytosis before preoperative chemoradiotherapy in rectal cancer: Predicting pathologic tumor response and oncologic outcome Annals of Surgical Oncology, January 28, 2015 Clinical Article
4 Survival paradox between stage IIB/C (T4N0) and stage IIIA (T1-2N1) colon cancer Annals of Surgical Oncology, January 28, 2015 Clinical Article
5 Blood neutrophil-lymphocyte ratio predicts survival in patients with advanced pancreatic cancer treated with chemotherapy Annals of Surgical Oncology, January 28, 2015 Clinical Article
6 Nomograms to predict survival and the risk for developing local or distant recurrence in patients with rectal cancer treated with optional short-term radiotherapy Annals of Oncology, January 28, 2015 Clinical Article
7 Dose-dense nonpegylated liposomal doxorubicin and docetaxel combination in breast cancer: dose-finding study Full Text The Oncologist, January 28, 2015 Clinical Article
8 Racial disparities in prostate cancer incidence rates by census division in the United States, 1999-2008 The Prostate, January 28, 2015 Clinical Article
9 Genetics of breast cancer: a topic in evolution Annals of Oncology, January 28, 2015 Review Article
10 Potential for proteomic approaches in determining efficacy biomarkers following administration of fish oils rich in omega-3 fatty acids: application in pancreatic cancers Nutrition in Clinical Practice, January 28, 2015 Review Article
11 Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men Full Text European Urology, January 28, 2015
12 Nipple-sparing mastectomy in BRCA1/2 mutation carriers: An interim analysis and review of the literature Annals of Surgical Oncology, January 28, 2015 Clinical Article
13 Neoadjuvant chemoradiotherapy improves histological results compared with perioperative chemotherapy in locally advanced esophageal adenocarcinoma Annals of Surgical Oncology, January 28, 2015 Clinical Article
14 Salvage lymphadenectomy versus salvage radiotherapy/chemoradiotherapy for recurrence in cervical lymph node after curative resection of esophageal squamous cell carcinoma Annals of Surgical Oncology, January 28, 2015 Clinical Article
15 More extensive pelvic lymph node dissection improves survival in patients with node-positive prostate cancer Full Text European Urology, January 28, 2015 Clinical Article
16 Proposal of new classification for stage III colon cancer based on the lymph node ratio: Analysis of 4,172 patients from multi-institutional database in Japan Annals of Surgical Oncology, January 28, 2015 Clinical Article
17 Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients Annals of Surgical Oncology, January 28, 2015 Clinical Article
18 Multicenter assessment of neoadjuvant chemotherapy for muscle-invasive bladder cancer Full Text European Urology, January 28, 2015 Clinical Article
19 Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience Full Text BMC Cancer, January 28, 2015 Clinical Article
20 Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure Full Text BMC Cancer, January 28, 2015 Clinical Article
As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).
As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.
As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.
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