Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
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1 Circulating levels of immune and inflammatory markers and long versus short survival in early-stage lung cancer Annals of Oncology, May 21, 2013
2 Breast cancer phenotype, nodal status and palpability may be useful in the detection of overdiagnosed screening-detected breast cancers Annals of Oncology, May 21, 2013
3 Breast density and breast cancer risk by mammogram timing Cancer Epidemiology, Biomarkers & Prevention, May 21, 2013
4 HPV genotypes and risk of precancer Cancer Epidemiology, Biomarkers & Prevention, May 21, 2013
5 ZIP4 is a novel molecular marker for glioma Neuro-Oncology, May 21, 2013
6 Histology and smoking status predict survival of patients with advanced non-small-cell lung cancer: results of West Japan Oncology Group (WJOG) Study 3906l Journal of Thoracic Oncology, May 21, 2013
7 Phase 2 study of sorafenib in malignant mesothelioma previously treated with platinum-containing chemotherapy Journal of Thoracic Oncology, May 21, 2013 Clinical Article
8 DLC-1 is a candidate biomarker methylated and down-regulated in pancreatic ductal adenocarcinoma Tumor Biology, May 21, 2013 Clinical Article
9 Solar UV radiation and cancer in young children Cancer Epidemiology, Biomarkers & Prevention, May 21, 2013 Clinical Article
10 Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomised controlled trial Journal of Cancer Survivorship, May 21, 2013 Clinical Article
11 Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma Full Text OncoTargets and Therapy, May 21, 2013 Review Article Clinical Article
12 KEAP1 is a redox-sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells Cancer Research, May 21, 2013 Review Article
13 IRON-HF study: A randomized trial to assess the effects of iron in heart failure patients with anemia International Journal of Cardiology, May 21, 2013 Clinical Article
14 Phase I study of temozolomide combined with oral etoposide in children with malignant glial tumors Journal of Neuro-Oncology, May 21, 2013 Clinical Article
15 Gemcitabine, oxaliplatin and dexamethasone as salvage treatment for elderly patients with refractory and relapsed peripheral T-cell lymphoma Leukemia and Lymphoma, May 21, 2013 Clinical Article
16 Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism Cancer Research, May 21, 2013 Clinical Article
17 Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells Cancer Research, May 21, 2013 Clinical Article
18 Epidemiological characteristics of hepatocellular carcinoma in Egypt: A retrospective analysis of 1313 cases Liver International, May 21, 2013 Review Article
19 Overdiagnosis in breast cancer screening: the importance of length of observation period and lead time Breast Cancer Research, May 21, 2013 Clinical Article
20 Mutations and prognosis in primary myelofibrosis Leukemia, May 21, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial European Journal of Cancer, April 2, 2013
2 R-CVP versus R-CHOP versus R-FM for the initial treatment of patients with advanced-stage follicular lymphoma: Results of the FOLL05 Trial conducted by the Fondazione Italiana Linfomi Journal of Clinical Oncology, April 1, 2013
3 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 2, 2013 Clinical Guideline
4 Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study Annals of Oncology, April 3, 2013
5 Phase 2 study of dose-intense temozolomide in recurrent glioblastoma Neuro-Oncology, April 9, 2013
6 Estrogen plus progestin and breast cancer incidence and mortality in the Women's Health Initiative Observational Study Journal of the National Cancer Institute, April 4, 2013
7 Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments BMC Cancer, April 3, 2013 Free full text
8 Exemestane Versus Anastrozole in Postmenopausal Women With Early Breast Cancer: NCIC CTG MA.27--A Randomized Controlled Phase III Trial Journal of Clinical Oncology, February 11, 2013
9 Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial The Lancet Oncology, March 12, 2013
10 Effect of low-dose tamoxifen after surgical excision of ductal intraepithelial neoplasia: results of a large retrospective monoinstitutional cohort study Annals of Oncology, April 1, 2013
11 High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma European Journal of Cancer, April 5, 2013
12 Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2×2 factorial trial The Lancet Oncology, April 12, 2013
13 Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202) Journal of Clinical Oncology, April 15, 2013
14 Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors Cancer, April 11, 2013
15 Comparative effectiveness of three platinum-doublet chemotherapy regimens in elderly patients with advanced non-small cell lung cancer Cancer, April 10, 2013
16 Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial The Lancet Oncology, February 15, 2013
17 Neoadjuvant chemotherapy with paclitaxel and everolimus in breast cancer patients with non-responsive tumours to epirubicin/cyclophosphamide (EC)±bevacizumab: Results of the randomised GeparQuinto study (GBG 44) European Journal of Cancer, April 5, 2013
18 Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial Annals of Oncology, April 4, 2013
19 Antitumour activity of abiraterone acetate against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100) Annals of Oncology, April 16, 2013
20 R-CHOP therapy alone in limited stage diffuse large B-cell lymphoma British Journal of Haematology, March 1, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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