The Latest Journal Articles in Oncology

1Oncotype Dx assay and breast cancer in the United States: usage and concordance with chemotherapyBreast Cancer Research and Treatment, April 24, 2015  Clinical Article
2Donepezil for irradiated brain tumor survivors: A phase III randomized placebo-controlled clinical trialJournal of Clinical Oncology, April 24, 2015  Clinical Article
3Impact of specific epidermal growth factor receptor (EGFR) mutations and clinical characteristics on outcomes after treatment with EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR-mutant lung cancer: a meta-analysisJournal of Clinical Oncology, April 24, 2015  Evidence Based Medicine
4A randomized, placebo-controlled phase III trial of masitinib plus gemcitabine in the treatment of advanced pancreatic cancerAnnals of Oncology, April 24, 2015  Clinical Article
5Survival following early-stage colon cancer: an ACCENT-based comparison of patients versus a matched international general populationAnnals of Oncology, April 24, 2015  Clinical Article
6Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancerBMC Cancer, April 24, 2015  Full Text  Clinical Article
7Subgroup analyses in reporting of phase III clinical trials in solid tumorsJournal of Clinical Oncology, April 24, 2015  Clinical Article
8Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancerAnnals of Oncology, April 24, 2015  Clinical Article
9A phase I/II trial of second-line chemotherapy with paclitaxel and irinotecan in fluoropyrimidine- and platinum-pretreated patients with advanced gastric cancerCancer Chemotherapy and Pharmacology, April 24, 2015  Clinical Article
10Comparison of multi-frequency bioimpedance with perometry for the early detection and intervention of lymphoedema after axillary node clearance for breast cancerBreast Cancer Research and Treatment, April 24, 2015  Clinical Article
1Scientists detect lymphoma relapse by monitoring cell-free tumor DNAStanford School of Medicine News, April 24, 2015
2Pancreatic cancer breakthrough: Scientists turn cancer cells into normal cellsSanford-Burnham Medical Research Institute News, April 24, 2015
3Detecting lung cancer at an early stageRuhr-Universitaet-Bochum News, April 24, 2015
4Nih-funded research leads to approval of drug for acute radiation injuryNational Institute of Allergy and Infectious Disease - News, April 24, 2015
5More detailed findings confirm that coffee protects against breast cancer recurrenceLund University News, April 24, 2015
6Scientists discover genetic cause of deadly rare disease ‘dyskeratosis congenita’Queen Mary University of London News, April 24, 2015
7Study illuminates role of cancer drug decitabine in repairing damaged cellsPurdue University Research news, April 24, 2015
8Study sheds new light on a crucial enzyme for the immune responseUniversite de Montreal News, April 24, 2015
9Potential new target to prevent breast cancer relapseThe University of Adelaide News, April 24, 2015
10Triple negative breast cancer in African-American women has distinct differenceGeorgetown University Medical Center News, April 24, 2015

Show Me:

Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas

As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.

YKL-40 predicts poor prognosis for bladder cancer

As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).

VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

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Clinical Pearls

Clinical Pearl from Smartest DocTumor levels of CD133 and survivin may be useful biomarkers for predicting early intrahepatic recurrence.

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