VPAC1 overexpression associated with colon cancer aggression
As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.
Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas
As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.
Increased incidence of second primary cancers in patients with salivary gland tumors
As reported in JAMA—Otolaryngology-Head & Neck Surgery, patients with salivary gland tumors have an increased risk of second primary tumors and newly developed cancers. Specifically, the cumulative 2-, 5-, and 10-year rates for second primary cancers are 4.4%, 8.3%, and 12.4%, respectively. Similarly, the cumulative 2-, 5-, and 10-year rates for newly diagnosed cancers are 1.1%, 3.4%, and 10.5%, respectively.