We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Prospective clinical utility study of the use of the 21-gene assay in adjuvant clinical decision making in women with estrogen receptor-positive early invasive breast cancer: Results from the SWITCH StudyThe Oncologist, July 03, 2015  Full Text  Clinical Article
2Pemetrexed plus cisplatin versus gemcitabine plus cisplatin according to thymidylated synthase expression in nonsquamous non–small-cell lung cancer: a biomarker-stratified randomized phase ii trialJournal of Clinical Oncology, July 03, 2015  Clinical Article
3Inhibition of breast cancer cell migration by activation of cAMP signalingBreast Cancer Research and Treatment, July 03, 2015  Clinical Article
4Citrus consumption and risk of cutaneous malignant melanomaJournal of Clinical Oncology, July 03, 2015  Clinical Article
5Pemetrexed plus cisplatin versus gemcitabine plus cisplatin according to thymidylated synthase expression in non-squamous non–small-cell lung cancer: A biomarker-stratified randomized phase II trialJournal of Clinical Oncology, July 03, 2015  Clinical Article
6Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: Retrospective analysis of the AVAglio trialJournal of Clinical Oncology, July 03, 2015  Clinical Article
7Adjuvant taxane-based chemotherapy for early stage breast cancer: A real-world comparison of chemotherapy regimens in OntarioBreast Cancer Research and Treatment, July 03, 2015  Clinical Article
8Early relapse of follicular lymphoma after rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone defines patients at high risk for death: An analysis from the National LymphoCare StudyJournal of Clinical Oncology, July 03, 2015  Clinical Article
9Patterns of care and clinical outcomes of first-line trastuzumab-based therapy in HER2-positive metastatic breast cancer patients relapsing after (neo)adjuvant trastuzumab: An Italian multicenter retrospective cohort studyThe Oncologist, July 03, 2015  Full Text  Clinical Article
10Phase I imaging and pharmacodynamic trial of CS-1008 in patients with metastatic colorectal cancerJournal of Clinical Oncology, July 03, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Studies find therapy changes, personalized treatment can improve outcomes for childhood kidney cancer patientsChildren’s National Medical Center, July 03, 2015
2Improved survival in adult patients with low-grade brain tumorsUC San Diego Health System, July 03, 2015
3Ferrer and IDIBELL develop EPICUP, the first epigenetic test for patients with cancer of unknown originIDIBELL-Bellvitge Biomedical Research Institute News, July 03, 2015
4Tanning bed use declines, new study showsFred Hutchinson Cancer Research Center News, July 03, 2015
5How removing a protein slows blood vessel growth in tumoursUniversity of Leeds Health News, July 03, 2015
6Subcutaneous administration of multispecific antibody makes tumor treatment faster and more tolerableHelmholtz Zentrum München - German Research Center for Environmental Health News, July 03, 2015
7Fishing for clues - how ‘liquid biopsies’ are uncovering cancer's secretsCancer Research UK News, July 03, 2015
8Women's lung cancer cases hit 20,000Cancer Research UK News, July 03, 2015
9Live imaging reveals how wound healing influences cancerEMBO News, July 03, 2015
10World GI 2015: Patients with lowest BMI have shortest survival in pooled analysis of bevacizumab in metastatic colorectal cancerEuropean Society for Medical Oncology News, July 03, 2015

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VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas

As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.

Increased incidence of second primary cancers in patients with salivary gland tumors

As reported in JAMA—Otolaryngology-Head & Neck Surgery, patients with salivary gland tumors have an increased risk of second primary tumors and newly developed cancers. Specifically, the cumulative 2-, 5-, and 10-year rates for second primary cancers are 4.4%, 8.3%, and 12.4%, respectively. Similarly, the cumulative 2-, 5-, and 10-year rates for newly diagnosed cancers are 1.1%, 3.4%, and 10.5%, respectively.

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Clinical Pearls

Clinical Pearl from Smartest DocPseudocapsule is most commonly found in the clear cell renal carcinoma subtype.

Clinical Pearl from Smartest DocAn ovarian tumor involving one or both ovaries with pelvic extension is defined as stage II disease according to the FIGO staging system.

Clinical Pearl from Smartest DocOmega-3 fatty acid supplementation has no observable effect on cancer risk.

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