Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation The Lancet Oncology, August 22, 2014    Clinical Article

2 Chk1 Inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers Full Text BMC Cancer, August 22, 2014    Clinical Article

3 Phase I/randomized phase II study of afatinib, an irreversible ErbB family blocker, with or without protracted temozolomide in adults with recurrent glioblastoma Neuro-Oncology, August 22, 2014    Clinical Article

4 Bone complications among prostate cancer survivors: Long-term follow-up from the prostate cancer outcomes study Prostate Cancer & Prostatic Diseases, August 22, 2014    Clinical Article

5 Extraprostatic extension of prostatic carcinoma: Is its proximity to surgical margin or gleason score important? BJU International, August 22, 2014    Clinical Article

6 Temozolomide after radiotherapy in recurrent low grade diffuse brainstem glioma in adults Journal of Neuro-Oncology, August 22, 2014    Clinical Article

7 Surgical resection is better than transarterial chemoembolization for hepatocellular carcinoma beyond Milan criteria independent of performance status Journal of Gastrointestinal Surgery, August 22, 2014    Clinical Article

8 Factors affecting cosmesis after breast conserving surgery without oncoplastic techniques in an experienced comprehensive breast center The Surgeon, August 22, 2014    Clinical Article

9 Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide Endocrine-Related Cancer, August 22, 2014    Clinical Article

10 Outcomes in the surgical treatment of low rectal cancer: does neoadjuvant treatment equalize results? ANZ Journal of Surgery, August 22, 2014

11 Impact of preoperative CECT on iodine retention Journal of Surgical Research, August 22, 2014    Clinical Article

12 The falling incidence of hematologic cancer after heart transplantation Clinical Transplantation, August 22, 2014    Clinical Article

13 MicroRNAs: A new key in lung cancer Cancer Chemotherapy and Pharmacology, August 22, 2014    Clinical Article

14 miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis Full Text Molecular Cancer, August 22, 2014    Clinical Article

15 Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma Full Text Molecular Cancer, August 22, 2014    Clinical Article

16 Morbidity and mortality following elective splenectomy for benign and malignant hematologic conditions: Analysis of the American College of Surgeons National Surgical Quality Improvement Program data JAMA Surgery, August 22, 2014    Review Article

17 HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients British Journal of Cancer, August 22, 2014    Clinical Article

18 Biology of advanced uveal melanoma and next steps for clinical therapeutics Pigment Cell & Melanoma Research, August 22, 2014    Review Article

19 Effects of selective inhibitors of Aurora kinases on anaplastic thyroid carcinoma cell lines Endocrine-Related Cancer, August 22, 2014    Clinical Article

20 Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death Cancer Chemotherapy and Pharmacology, August 22, 2014    Clinical Article

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Clinical Pearls in Oncology

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Highlights in Oncology

VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).

Increased incidence of second primary cancers in patients with salivary gland tumors

As reported in JAMA—Otolaryngology-Head & Neck Surgery, patients with salivary gland tumors have an increased risk of second primary tumors and newly developed cancers. Specifically, the cumulative 2-, 5-, and 10-year rates for second primary cancers are 4.4%, 8.3%, and 12.4%, respectively. Similarly, the cumulative 2-, 5-, and 10-year rates for newly diagnosed cancers are 1.1%, 3.4%, and 10.5%, respectively.

Other Topics in Oncology

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