The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.
1 Phase III study on efficacy of taxanes plus bevacizumab with or without capecitabine as first-line chemotherapy in metastatic breast cancer Breast Cancer Research and Treatment, December 19, 2014 Clinical Article
2 Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production Breast Cancer Research and Treatment, December 19, 2014 Clinical Article
3 Risk of subsequent cutaneous malignancy in patients with prior melanoma: a systematic review and meta-analysis Journal of the European Academy of Dermatology and Venereology, December 19, 2014 Evidence Based Medicine Review Article
4 Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: A meta-analysis Medical Oncology, December 19, 2014 Evidence Based Medicine
5 The value of serum Cyfra21-1 as a biomarker in the diagnosis of patients with non-small cell lung cancer: A meta-analysis Journal of Cancer Research and Therapeutics, December 19, 2014 Evidence Based Medicine
6 Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in very platinum-sensitive ovarian cancer patients: Results from a subset analysis of the CALYPSO phase III trial European Journal of Cancer, December 19, 2014 Clinical Article
7 Comparison of prostate cancer gene 3 score, prostate health index and percentage free prostate-specific antigen for differentiating histological inflammation from prostate cancer and other non-neoplastic alterations of the prostate at initial biopsy Anticancer Research, December 19, 2014 Clinical Article
8 Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer Journal of Clinical Oncology, December 19, 2014 Clinical Article
9 Differentially regulated miRNAs as prognostic biomarkers in the blood of primary CNS lymphoma patients European Journal of Cancer, December 19, 2014 Clinical Article
10 Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study Cancer Research, December 19, 2014 Clinical Article
11 Risk of diabetes among patients receiving primary androgen deprivation therapy for clinically localized prostate cancer The Journal of Urology, December 19, 2014 Clinical Article
12 The efficacy of irinotecan, paclitaxel, and oxaliplatin (IPO) in relapsed germ cell tumors with high dose chemotherapy as consolidation - A non-cisplatin- based induction approach BJU International, December 19, 2014 Clinical Article
13 The pharmacokinetics of a B-domain truncated recombinant FVIII, turoctocog alfa (NovoEight), in patients with hemophilia A Journal of Thrombosis and Haemostasis, December 19, 2014 Clinical Article
14 Prognostic significance of visceral pleural involvement in early-stage lung cancer Chest, December 19, 2014 Clinical Article
15 Analysis of patient-reported outcomes from the LUME-Lung 1 trial: A randomised, double-blind, placebo-controlled, Phase III study of second-line nintedanib in patients with advanced non-small cell lung cancer European Journal of Cancer, December 19, 2014 Clinical Article
16 A network meta-analysis of progression free survival and overall survival in first-line treatment of chronic lymphocytic leukemia Cancer Treatment Reviews, December 19, 2014 Clinical Article
17 Serum hepcidin-25 level linked with high mortality in patients with non-Hodgkin lymphoma Annals of Hematology, December 19, 2014 Clinical Article
18 MET amplification status in therapy-naive adeno- and squamous cell carcinomas of the lung Clinical Cancer Research, December 19, 2014 Clinical Article
19 Pharmacokinetics of concomitant cisplatin and paclitaxel administered by hyperthermic intraperitoneal chemotherapy to patients with peritoneal carcinomatosis from epithelial ovarian cancer British Journal of Cancer, December 19, 2014 Clinical Article
20 It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer British Journal of Cancer, December 19, 2014 Clinical Article
As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.
As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.
As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.