Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases: A phase II multi-institutional trial Journal of Clinical Oncology, October 31, 2014    Clinical Article

2 Endocrine therapy with or without inhibition of epidermal growth factor receptor and human epidermal growth factor receptor 2: A randomized, double-blind, placebo-controlled phase III trial of fulvestrant with or without lapatinib for postmenopausal women with hormone receptor–positive advanced breast cancer Journal of Clinical Oncology, October 31, 2014    Clinical Article

3 PLEKHA5 as a biomarker and potential mediator of melanoma brain metastasis Clinical Cancer Research, October 31, 2014    Clinical Article

4 Diabetes, diabetes treatment and breast cancer prognosis Breast Cancer Research and Treatment, October 31, 2014    Clinical Article

5 A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: Translational Breast Cancer Research Consortium trial 007 Breast Cancer Research and Treatment, October 31, 2014    Clinical Article

6 Comparison of cetuximab to bevacizumab as the first-line bio-chemotherapy for patients with metastatic colorectal cancer: Superior progression-free survival is restricted to patients with measurable tumors and objective tumor response—a retrospective study Journal of Cancer Research & Clinical Oncology, October 31, 2014    Clinical Article

7 The association between infections and chemotherapy interruptions among cancer patients: Prospective cohort study Journal of Infection, October 31, 2014    Clinical Article

8 HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: A population-based study The Lancet Haematology, October 31, 2014    Clinical Article

9 Adjuvant radiation therapy for breast cancer in patients with schizophrenia The American Journal of Surgery, October 31, 2014    Clinical Article

10 Anastomotic leakage and presacral abscess formation after locally advanced rectal cancer surgery: Incidence, risk factors and treatment European Journal of Surgical Oncology, October 31, 2014    Clinical Article

11 Bendamustine and prednisone in combination with bortezomib (BPV) in the treatment of patients with newly diagnosed/untreated multiple myeloma Journal of Cancer Research & Clinical Oncology, October 31, 2014    Clinical Article

12 Infiltrating S100A8+ myeloid cells promote metastatic spread of human breast cancer and predict poor clinical outcome Breast Cancer Research and Treatment, October 31, 2014    Clinical Article

13 Have the American College of Surgeons Oncology Group Z0011 trial results influenced the number of lymph nodes removed during sentinel lymph node dissection? The American Journal of Surgery, October 31, 2014    Clinical Article

14 Effect of functional nuclear factor-κB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma Annals of Oncology, October 31, 2014    Clinical Article

15 Discrepancies between FISH and immunohistochemistry for assessment of the ALK status are associated with ALK "borderline"-positive rearrangements or a high copy number: A potential major issue for anti-ALK therapeutic strategies Annals of Oncology, October 31, 2014    Clinical Article

16 Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens Clinical Cancer Research, October 31, 2014    Clinical Article

17 Do environmental factors modify the genetic risk of prostate cancer? Cancer Epidemiology, Biomarkers & Prevention, October 31, 2014    Clinical Article

18 Increasing use of observation among men at low risk for prostate cancer mortality The Journal of Urology, October 31, 2014    Clinical Article

19 Practice patterns and individual variability of surgeons performing radical prostatectomies at a high volume academic center The Journal of Urology, October 31, 2014    Clinical Article

20 Sexual partners, sexually transmitted infections, and prostate cancer risk Cancer Epidemiology, October 31, 2014    Clinical Article

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Clinical Pearls in Oncology

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Highlights in Oncology

VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas

As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.

CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).

Other Topics in Oncology

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