We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Second-line dovitinib (TKI258) in patients with FGFR2-mutated or FGFR2-non-mutated advanced or metastatic endometrial cancer: a non-randomised, open-label, two-group, two-stage, phase 2 studyThe Lancet Oncology, May 22, 2015  Clinical Article
2Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cellsThe Lancet Haematology, May 22, 2015  Clinical Article
3Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trialsThe Lancet Haematology, May 22, 2015  Clinical Article
4Clinical usefulness of PI3K/Akt/mTOR genotyping in companion with other clinical variables in metastatic renal cell carcinoma patients treated with everolimus in the second and subsequent linesAnnals of Oncology, May 22, 2015  Clinical Article
5Adjuvant radiation therapy in locally advanced non-small cell lung cancer: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based clinical practice guidelinePractical Radiation Oncology, May 22, 2015
6Initial safety report on the tolerability of modified FOLFOX6 as adjuvant therapy in patients with curatively resected stage II or III colon cancer (JFMC41-1001-C2: JOIN trial)Cancer Chemotherapy and Pharmacology, May 22, 2015  Clinical Article
7Patient and treatment factors associated with survival among adult glioblastoma patients: A USA population-based study from 2000–2010Journal of Clinical Neuroscience, May 22, 2015  Clinical Article
8Association of fludarabine pharmacokinetic/dynamic biomarkers with donor chimerism in nonmyeloablative HCT recipientsCancer Chemotherapy and Pharmacology, May 22, 2015  Clinical Article
9Development of a new equation to estimate creatinine clearance in cancer patientsCancer Chemotherapy and Pharmacology, May 22, 2015  Clinical Article
10Modeled risk of ischemic heart disease following left breast irradiation with deep inspiration breath holdPractical Radiation Oncology, May 22, 2015  Clinical Article

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We have Ranked, Sorted and Summarized the Latest Clinical Articles.

1Researchers focus on potential tool for predicting survival, staging prostate cancer in Cancer CellIndiana University School of Medicine News, May 22, 2015
2Chemo before surgery benefits patients with advanced ovarian cancerUniversity College London New, May 22, 2015
3More people are dying in hospicesKing's College London News, May 22, 2015
4Surgery followed by ipilimumab treatment in melanoma patients improves survival, say Moffitt Cancer Center researchersH. Lee Moffitt Cancer Center & Research Institute News, May 22, 2015
5Survey of health care providers and patients highlights need for standardization of use of the breast cancer drug, docetaxelOttawa Hospital Research Institute News, May 22, 2015
6Contraceptive and cholesterol-lowering drugs used to treat cancerUniversity of Birmingham Medical News, May 22, 2015
7Patient interest, willingness to pay out of pocket costs for tumor genetic profiling assessed by Fox Chase researchersFox Chase Cancer Center News, May 22, 2015
8International study of advanced prostate cancer genome finds abundance of potential targets for drug therapyDana-Farber Cancer Institute, May 22, 2015
9New chemical technology boosts potency of targeted cancer therapyDana-Farber Cancer Institute, May 22, 2015
10Molecule designed to treat lung cancer shows promising results in miceJohns Hopkins Medicine, May 21, 2015

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CHD7 associated with survival in pancreatic ductal adenocarcinoma patients receiving gemcitabine

As reported in Cancer Research, low CHD7 expression is associated with increased RFS and OS in pancreatic ductal adenocarcinoma patients receiving gemcitabine. There was no association between CHD7 expression and RFS or OS in patients who were not treated with gemcitabine.

YKL-40 predicts poor prognosis for bladder cancer

As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).

VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

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Clinical Pearls

Clinical Pearl from Smartest DocMohs micrographic surgery is an effective treatment strategy for basoquamous carcinoma and metatypical basal cell carcinoma.

Clinical Pearl from Smartest DocMultivitamin use in post-menopausal women with invasive breast cancer may decrease the risk of breast cancer mortality.

Clinical Pearl from Smartest DocRadiotherapy has a role in the treatment of melanoma.

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