The Latest Clinical Articles in Oncology & Cancer

1Early life body fatness and risk of colorectal cancer in U.S. women and men—results from two large cohort studiesCancer Epidemiology, Biomarkers & Prevention, April 02, 2015  Clinical Article
2De-novo post-diagnosis aspirin use and mortality in women with stage I-III breast cancerCancer Epidemiology, Biomarkers & Prevention, April 02, 2015  Clinical Article
3Open-label phase 1b study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer who have progressed following chemotherapy for advanced or metastatic diseaseCancer Chemotherapy and Pharmacology, April 02, 2015  Clinical Article
4Music therapy is associated with family perception of more spiritual support and decreased breathing problems in cancer patients receiving hospice careJournal of Pain and Symptom Management, April 02, 2015  Clinical Article
5%[-2]proPSA and "prostate health index" (PHI) improve the diagnostic accuracy for clinically relevant prostate cancer at initial and repeat biopsy compared to t-PSA and %f-PSA in men ≤ 65 years oldBJU International, April 02, 2015  Clinical Article
6Metabolic syndrome, dyslipidemia and prostate cancer recurrence after primary surgery or radiation in a veterans cohortProstate Cancer & Prostatic Diseases, April 02, 2015  Clinical Article
7A randomised phase 2 trial of dexamethasone versus prednisolone in castration-resistant prostate cancerEuropean Urology, April 02, 2015  Full Text  Clinical Article
8Active surveillance for prostate cancer: A systematic review of clinicopathologic variables and biomarkers for risk stratificationEuropean Urology, April 02, 2015  Full Text  Evidence Based Medicine  Review Article
9Gemcitabine, oxaliplatin, and capecitabine (GEMOXEL) compared with gemcitabine alone in metastatic pancreatic cancer: A randomized phase II studyCancer Chemotherapy and Pharmacology, April 02, 2015  Clinical Article
10Screening magnetic resonance imaging recommendations and outcomes in patients at high risk for breast cancerThe Breast Journal, April 02, 2015  Clinical Article
1Study suggests precision medicine for adrenal cancerUniversity of Michigan Health System, April 02, 2015
2Study of breast biopsies shows rate of pathologists' discordUW Medicine, April 02, 2015
3Serious risks from common IV devices mean doctors should choose carefully, U-M experts sayUniversity of Michigan Health System, April 02, 2015
4New insights into survival outcomes of Asian Americans diagnosed with cancerBrigham and Women's Hospital, April 02, 2015
5Could a tampon help predict endometrial cancer? Mayo Clinic researchers say yesMayo Clinic, April 02, 2015
6Incidence of colorectal cancer increasing in young people: Family doctors urged to be on the alert for alarm symptomsUnited European Gastroenterology News, April 02, 2015
7FDA drug safety communication: FDA strengthens warnings and changes prescribing instructions to decrease the risk of serious allergic reactions with anemia drug Feraheme (ferumoxytol)FDA What's New: Drugs, April 02, 2015
8Low vitamin D linked to worse prognosis in type of Non-Hodgkin lymphomaUniversity of Rochester Medical Center, April 02, 2015
9Researchers develop new potential drug for rare leukemiaUniversity of Michigan Health System, April 02, 2015
10Control switch that modulates cell stress response may be key to multiple diseasesUC San Diego Health System, April 02, 2015

Show Me:

CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).

VPAC1 overexpression associated with colon cancer aggression

As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.

YKL-40 predicts poor prognosis for bladder cancer

As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).

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