Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma
Human Pathology, 06/21/2012
Rahman M et al. – The findings suggest that no association of PIK3CA mutations was found between positive phosphorylated AKT and positive phosphorylated mTOR, which suggests that the PI3K/AKT/mTOR pathway may be activated by other molecular mechanisms. Although PIK3CA mutations were associated with a more favorable prognosis, they did not predict the sensitivity of ovarian clear cell carcinoma cells to PI3K/AKT/mTOR inhibitors.