Vitamin D and the mammary gland: a review on its role in normal development and breast cancer Full Text
Breast Cancer Research,  Review Article

Lopes N. et al .– The present review highlights research data concerning the function of Vitamin D hormone in the mammary gland, with a special focus on breast carcinogenesis. Hence, and although the available data are controversial, the authors consider not only updated information on the epidemiology of vitamin D in breast cancer and its potential value as a therapeutic agent or prophylactic (with an emphasis on molecular mechanisms and effectors of vitamin D action), but include data on its role in other stages of breast cancer progression as well. Accordingly, they also review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D–related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ.

  • Breast cancer is a heterogeneous disease associated with diverse biological behaviours and clinical outcome.
  • Although some molecular subgroups of breast cancer have a targeted therapy, the most aggressive tumours still lack a molecular target.
  • Despite vitamin D being classically associated with the physiological role of calcium regulation and phosphate transport in bone metabolism, several studies have demonstrated a wide range of functions for this hormone, which are particularly important in the field of cancer.
  • The mechanisms underlying the protective actions of vitamin D in cancer development are only sparsely understood, but evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell differentiation.
  • In addition, it has been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis.
  • Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1.
  • The data described provide evidence for an essential role of vitamin D in normal development of the mammary gland and breast cancer.
  • Epidemiological studies are conflicting and their results not consistent, with the current view indicating no protective role for vitamin D in breast cancer development.
  • Still, the different functions and effects of vitamin D on cancer cell biology, such as the cell cycle, apoptosis, invasion and metastasis, as well as angiogenesis, virtually bring together the entire spectrum of tumour development under its purview.

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