Vitamin D and the mammary gland: a review on its role in normal development and breast cancer Full Text
Breast Cancer Research,  Review Article

Lopes N. et al .– The present review highlights research data concerning the function of Vitamin D hormone in the mammary gland, with a special focus on breast carcinogenesis. Hence, and although the available data are controversial, the authors consider not only updated information on the epidemiology of vitamin D in breast cancer and its potential value as a therapeutic agent or prophylactic (with an emphasis on molecular mechanisms and effectors of vitamin D action), but include data on its role in other stages of breast cancer progression as well. Accordingly, they also review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D–related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ.

  • Breast cancer is a heterogeneous disease associated with diverse biological behaviours and clinical outcome.
  • Although some molecular subgroups of breast cancer have a targeted therapy, the most aggressive tumours still lack a molecular target.
  • Despite vitamin D being classically associated with the physiological role of calcium regulation and phosphate transport in bone metabolism, several studies have demonstrated a wide range of functions for this hormone, which are particularly important in the field of cancer.
  • The mechanisms underlying the protective actions of vitamin D in cancer development are only sparsely understood, but evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell differentiation.
  • In addition, it has been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis.
  • Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1.
  • The data described provide evidence for an essential role of vitamin D in normal development of the mammary gland and breast cancer.
  • Epidemiological studies are conflicting and their results not consistent, with the current view indicating no protective role for vitamin D in breast cancer development.
  • Still, the different functions and effects of vitamin D on cancer cell biology, such as the cell cycle, apoptosis, invasion and metastasis, as well as angiogenesis, virtually bring together the entire spectrum of tumour development under its purview.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Obstetrics & Gynecology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Obstetrics & Gynecology Articles

1 Fetal facial profile markers in second and third trimester trisomy 18 fetuses Ultrasound in Obstetrics & Gynecology, September 16, 2014    Clinical Article

2 A cost-effectiveness analysis comparing different strategies to implement noninvasive prenatal testing into a Down syndrome screening program Australian and New Zealand Journal of Obstetrics and Gynaecology, September 16, 2014    Clinical Article

3 Elevated maternal serum α-fetoprotein after minor trauma during pregnancy may predict adverse fetal outcomes The Journal of Trauma and Acute Care Surgery, September 12, 2014    Clinical Article

4 Obstetrical APS: Is there a place for hydroxychloroquine to improve the pregnancy outcome? Autoimmunity Reviews, September 3, 2014    Review Article

5 The consistency of experts' evaluation of obstetric claims for compensation BJOG: An International Journal of Obstetrics and Gynaecology, September 8, 2014    Clinical Article

6 Maternal periconceptional occupational pesticide exposure and neural tube defects Birth Defects Research Part A: Clinical and Molecular Teratology, August 26, 2014

7 BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin Oncogene, September 5, 2014    Clinical Article

8 Circulating endometrial cells in peripheral blood European Journal of Obstetrics & Gynecology and Reproductive Biology, September 8, 2014    Clinical Article

9 In utero resolution of microcystic congenital cystic adenomatoid malformation after prenatal betamethasone therapy: A report of three cases and a literature review Journal of Clinical Ultrasound, July 23, 2014

10 Serum microRNA-205 as a novel biomarker for cervical cancer patients Cancer Cell International, September 15, 2014    Clinical Article

11 l-carnitine supplementation during vitrification of mouse germinal vesicle stage–oocytes and their subsequent in vitro maturation improves meiotic spindle configuration and mitochondrial distribution in metaphase II oocytes Human Reproduction, September 22, 2014

12 Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects Birth Defects Research Part A: Clinical and Molecular Teratology, August 26, 2014

13 Physical activity and telomere length in early stage breast cancer survivors Breast Cancer Research, September 8, 2014    Clinical Article

14 Human trophoblasts confer resistance to viruses implicated in perinatal infection American Journal of Obstetrics and Gynecology, August 18, 2014    Clinical Article

15 The stemness of neural crest cells and their derivatives Birth Defects Research Part C: Embryo Today: Reviews, September 23, 2014

16 Connecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac function Birth Defects Research Part C: Embryo Today: Reviews, September 23, 2014

17 DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects Birth Defects Research Part A: Clinical and Molecular Teratology, August 29, 2014

18 Neonatal outcome after preimplantation genetic diagnosis Fertility and Sterility, August 1, 2014    Clinical Article

19 Human epidermal neural crest stem cells as candidates for cell-based therapies, disease modeling, and drug discovery Birth Defects Research Part C: Embryo Today: Reviews, September 23, 2014

20 Further evidence suggesting a role for variation in ARHGAP29 variants in nonsyndromic cleft lip/palate Birth Defects Research Part A: Clinical and Molecular Teratology, August 29, 2014    Clinical Article

Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecologymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More