Vitamin D and the mammary gland: a review on its role in normal development and breast cancer Full Text
Breast Cancer Research,  Review Article

Lopes N. et al .– The present review highlights research data concerning the function of Vitamin D hormone in the mammary gland, with a special focus on breast carcinogenesis. Hence, and although the available data are controversial, the authors consider not only updated information on the epidemiology of vitamin D in breast cancer and its potential value as a therapeutic agent or prophylactic (with an emphasis on molecular mechanisms and effectors of vitamin D action), but include data on its role in other stages of breast cancer progression as well. Accordingly, they also review data on the influence of vitamin D in the development of normal breast and the expression of vitamin D–related proteins (VDR, CYP27B1 and CYP24A21) in benign mammary lesions and ductal carcinomas in situ.

  • Breast cancer is a heterogeneous disease associated with diverse biological behaviours and clinical outcome.
  • Although some molecular subgroups of breast cancer have a targeted therapy, the most aggressive tumours still lack a molecular target.
  • Despite vitamin D being classically associated with the physiological role of calcium regulation and phosphate transport in bone metabolism, several studies have demonstrated a wide range of functions for this hormone, which are particularly important in the field of cancer.
  • The mechanisms underlying the protective actions of vitamin D in cancer development are only sparsely understood, but evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell differentiation.
  • In addition, it has been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis.
  • Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1.
  • The data described provide evidence for an essential role of vitamin D in normal development of the mammary gland and breast cancer.
  • Epidemiological studies are conflicting and their results not consistent, with the current view indicating no protective role for vitamin D in breast cancer development.
  • Still, the different functions and effects of vitamin D on cancer cell biology, such as the cell cycle, apoptosis, invasion and metastasis, as well as angiogenesis, virtually bring together the entire spectrum of tumour development under its purview.

Please login or register to follow this author.
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Obstetrics & Gynecology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Obstetrics & Gynecology Articles

1 Intracytoplasmic sperm injection (ICSI) of sub-optimal sperm increases the risk of sex-chromosome, but not autosomal aneuploidy among embryos evaluated with comprehensive chromosome screening (CCS) Fertility and Sterility, January 21, 2015

2 Non-invasive prenatal testing for trisomy 21 based on analysis of cell-free fetal dna circulating in the maternal plasma Prenatal Diagnosis, January 28, 2015

3 Outcomes of preimplantation genetic diagnosis in neurofibromatosis type 1 Fertility and Sterility, January 19, 2015    Clinical Article

4 Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death Breast Cancer Research, January 29, 2015    Clinical Article

5 Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome Human Reproduction, January 28, 2015    Clinical Article

6 Circulating cell free (ccf) DNA testing: Are some test failures informative? Prenatal Diagnosis, December 3, 2014

7 Noninvasive prenatal testing for trisomy 21, 18 and 13 - clinical experience from 146,958 pregnancies Ultrasound in Obstetrics & Gynecology, January 27, 2015    Clinical Article

8 Molecular basis of non-syndromic hypospadias: Systematic mutation screening and genome-wide copy-number analysis of 62 patients Human Reproduction, January 28, 2015    Clinical Article

9 Diagnosis of fetal submicroscopic chromosomal abnormality in failed array CGH samples - copy number by sequencing as an alternative to microarrays for fetal invasive testing Ultrasound in Obstetrics & Gynecology, January 5, 2015

10 Can microRNA profiling in maternal blood identify women at risk for preterm birth? American Journal of Obstetrics and Gynecology, January 28, 2015    Clinical Article

11 Use of CA125 and HE4 serum markers to predict ovarian cancer in elevated-risk women Cancer Epidemiology, Biomarkers & Prevention, June 25, 2014    Clinical Article

12 A high throughput screening system for predicting chemically-induced reproductive organ deformities Reproductive Toxicology, January 9, 2015

13 Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction Seminars in Fetal and Neonatal Medicine, January 23, 2015

14 Advances in revealing the molecular targets downstream of oxidative stress -induced pro-apoptotic kinase signaling in diabetic embryopathy American Journal of Obstetrics and Gynecology, January 28, 2015    Clinical Article

15 Factors affecting the utilization of genetic counseling services among Israeli Arab women Prenatal Diagnosis, January 7, 2015

16 Serum micrornas as diagnostic biomarkers for macrosomia Reproductive Sciences, January 8, 2015

17 Are the neuromotor disabilities of bilirubin-induced neurologic dysfunction disorders related to the cerebellum and its connections? Seminars in Fetal and Neonatal Medicine, January 13, 2015    Review Article

18 Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers Cancer Epidemiology, Biomarkers & Prevention, January 2, 2015    Clinical Article

19 Specific gene expression differences in cumulus cells as potential biomarkers of pregnancy Reproductive BioMedicine Online, January 23, 2015    Clinical Article

20 Effect of the FSH receptor single nucleotide polymorphisms (FSHR 307/680) on the follicular fluid hormone profile and the granulosa cell gene expression in human small antral follicles Molecular Human Reproduction, December 22, 2014

Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecologymore


The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List