Where else but MDLinx OB/GYN can you find all the literature published in over 2,000 top peer-reviewed medical journals, ranked and summarized for you every 24 hours? Our team of physician editors is dedicated to keeping you current in less than 5 minutes a day. We cover the entirety of your diverse specialty, with subspecialty topics chosen to address the information needs of the entire women’s healthcare team, including gynecologic oncology, maternal-fetal medicine, obstetric and gynecologic surgery, ped/adolescent gynecology, repro/endo and infertility, the breast, menopausal medicine, diagnostic imaging, and much more.
Also find bonus content on this page that includes articles highlighted by our physician editor, D. Scott Cunningham, MD, PhD, that are “must-read.” Additionally, because Maintenance of Certification (MOC) is always a concern, we will provide some of the recent clinical pearls related to Obstetrics & Gynecology from our Smartest Doc and Physician Review quizzes, many of which result from a collaboration with the Cleveland Clinic Center for Continuing Education.
Your Unread Messages in Obstetrics & Gynecology
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D Scott Cunningham MD, PhD
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1 Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test Full Text BMC Cancer, October 8, 2012
2 Negative Cross Talk between NFAT1 and Stat5 Signaling in Breast Cancer Full Text Molecular Endocrinology, October 8, 2012 Original Publication Date: October 7, 2011
3 The LiP (Lifestyle in Pregnancy) Study: A randomized controlled trial of lifestyle intervention in 360 obese pregnant women Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011
4 Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 6, 2011 Evidence Based Medicine Clinical Article
5 Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 6, 2011 Clinical Article
6 Risk of Breast Cancer After Onset of Type 2 Diabetes: Evidence of detection bias in postmenopausal women Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011
7 Prognostic importance of DNA ploidy and DNA index in stage I and II endometrioid adenocarcinoma of the endometrium Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 6, 2011
8 Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: lack of prediction in HER2-positive disease treated with targeted therapy Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 6, 2011
9 µ-Opioid Receptor Gene A118G Polymorphism Predicts Survival in Patients with Breast Cancer Full Text Anesthesiology, October 7, 2012 Original Publication Date: April 6, 2012
10 Does the Baricity of Bupivacaine Influence Intrathecal Spread in the Prolonged Sitting Position Before Elective Cesarean Delivery- A Prospective Randomized Controlled Study Full Text Anesthesia & Analgesia, October 6, 2012 Original Publication Date: October 5, 2011 Clinical Article
11 Effect of macronutrient intake during the second trimester on glucose metabolism later in pregnancy Full Text American Journal of Clinical Nutrition, October 6, 2012 Original Publication Date: October 5, 2011
12
Sleep Disturbances and Their Relationship to Glucose Tolerance in Pregnancy Full Text
Diabetes Care, October 5, 2012
Original Publication Date: October 4, 2011
Exclusive Author Commentary
13 Maternal Cardiac Output Changes After Crystalloid or Colloid Coload Following Spinal Anesthesia for Elective Cesarean Delivery: A Randomized Controlled Trial Full Text Anesthesia & Analgesia, October 5, 2012 Original Publication Date: October 4, 2011 Clinical Article
14 Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes Full Text Breast Cancer Research, October 5, 2012
15 Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines Full Text BMC Cancer, October 5, 2012
16 Cesarean does not improve fetal mortality with vertex–status early preterm delivery Full Text OBG Management, October 4, 2012 Clinical Article
17 Birth Weight, Breast Cancer and the Potential Mediating Hormonal Environment. Full Text OBG Management, October 4, 2012 Clinical Article
18 Pre-pregnancy care for women with pre-gestational diabetes mellitus: a systematic review and meta-analysis Full Text BMC Public Health, October 4, 2012 Evidence Based Medicine
19 Cost-effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in women with early-stage estrogen- or progesterone-receptor-positive, axillary lymph-node negative breast cancer Full Text BMC Cancer, October 4, 2012
20 Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells Full Text BMC Cancer, October 4, 2012
Based on a review article published in BMC Infectious Diseases, it has been concluded that antiseptics have equal efficacy to antibiotics in the treatment of bacterial vaginosis. The literature search covered the time period 1966-2010. Benzydamine, chlorhexidine, and polyhexamethylene niguanide were as effective as metronidazole and clindamycin in the short-term treatment of bacterial vaginosis.
Read the article summaryBased on an observational study orchestrated by researchers at the M D Anderson Cancer Center, BRCA2 mutations have been associated with improved survival in patients with high-grade serous ovarian cancer. The 5-year OS in patients with BRCA2 mutations was 61% compared with 25% for patients with BRCA wild-type. The 3-year PFS in patients with BRCA2 mutations was 44% compared with 16% for patients with BRCA wild-type. Patients with BRCA2 mutations exhibited 100% chemosensitivity compared to 82% and 80% for patients with BRCA wild-type and BRCA1 mutations, respectively. Genomic analysis of the tumors from patients with BRCA2 mutations suggested a “mutator phenotype” compared to tumors from patients with BRCA1 mutations.
Read the article summaryIn a study involving 87,025 postmenopausal women, those in the highest quintile of dietary trans fat had an increased risk of ischemic stroke (HR=1.39). In 663,041 person-years of follow-up, 1049 incident cases of ischemic stroke were reported. The effect was attenuated in aspirin users (HR=0.95) compared to non-users (HR=1.66).
Read the article summary1 Maternal position during caesarean section for preventing maternal and neonatal complications Cochrane Reviews, April 3, 2013
2 The relationship of serum anti-Mullerian hormone with polycystic ovarian morphology and polycystic ovary syndrome: a prospective cohort study Human Reproduction, April 4, 2013
3 Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes American Journal of Obstetrics and Gynecology, April 15, 2013
4 Antibiotics for mastitis in breastfeeding women Cochrane Reviews, March 8, 2013 Review Article
5 Loop Electrosurgical Excision Procedure and the Risk for Preterm Delivery Obstetrics and Gynecology, April 26, 2013
6 Methods of term labour induction for women with a previous caesarean section Cochrane Reviews, April 1, 2013 Review Article
7 Consequences of a Primary Elective Cesarean Delivery Across the Reproductive Life Obstetrics and Gynecology, April 5, 2013
8 Laparoscopic tubal re-anastomosis versus in vitro fertilization: cost- based decision analysis American Journal of Obstetrics and Gynecology, April 18, 2013
9 Current role of robotic hysterectomy Journal of Gynecologic Surgery, April 25, 2013
10 Randomized trial of Metformin versus Insulin in the Management of Gestational Diabetes American Journal of Obstetrics and Gynecology, March 29, 2013
11 Potential effects of updated pap test screening guidelines and adenocarcinoma in situ of the cervix Obstetrics and Gynecology, March 26, 2013
12 Menopause, estrogens and frailty Gynecological Endocrinology, April 16, 2013
13 Tachysystole in term labor: incidence, risk factors, outcomes, and effect on fetal heart tracings American Journal of Obstetrics and Gynecology, April 9, 2013
14 Cervical cancer screening: What’s new and what’s coming? Cleveland Clinic Journal of Medicine, March 19, 2013
15 The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet? Menopause International, April 11, 2013
16 Efficacy and Safety of Desvenlafaxine Treatment for Hot Flashes Associated with Menopause: A Meta-Analysis of Randomized Controlled Trials Gynecologic and Obstetric Investigation, April 12, 2013 Evidence Based Medicine Review Article
17 2012 Cervical Cancer Screening Guidelines and the Future Role of HPV Testing Clinical Obstetrics and Gynecology, February 4, 2013 Clinical Guideline
18 Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study British Medical Journal, April 23, 2013 Free full text
19 Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer New England Journal of Medicine, April 2, 2013
20 Light drinking versus abstinence in pregnancy-behavioural and cognitive outcomes in 7-year-old children: a longitudinal cohort study BJOG: An International Journal of Obstetrics and Gynaecology, April 18, 2013
Indexed Journals in Obstetrics & Gynecology: Obstetrics and Gynecology, American Journal of Obstetrics and Gynecology more
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